Islet size has recently been demonstrated to be an important factor in determining human islet transplantation outcomes. In this study, a multi-layered microfluidic device was developed and quantified for size-based separation of a heterogeneous population of mouse islets. The device was fabricated using standard soft lithography and polydimethylsiloxane (PDMS). Size-based separation was first ...

We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated proliferation rate. Our formulation is based on an age-dependent stochastic process. Cells within the population are characterised by their age (i.e. time elapsed s...

Current life cycle impact assessment (LCIA) practices use a characterization factor to linearly scale chemical emission human health assuming homogeneous exposure and toxicological susceptibility for the entire population. However, both may vary within population, making same elicit disproportionate impacts. Here we explore how inter-individual variabilities in interact affect estimated overall...

background: inversion of the uterus is very uncommon. patients may present with pelvic pain, vaginal discharge, or hemodynamic shock. case: we report a case of 35 years old women (virgin) who was admitted with profuse vaginal bleeding and cramps of uterus. in the vaginal examination at litothomy position a mass of 58 cm in size was protruded from the vagina. at first myomectomy was performed a...

The paper presents an approach for set-membership estimation of the state of a heterogeneous population in which an infectious disease is spreading. The population state may consist of susceptible, infected, recovered, etc. groups, where the individuals are heterogeneous with respect to traits, relevant to the particular disease. Set-membership estimations in this context are reasonable, since ...

Recent empirical observations suggest a heterogeneous nature of human activities. The heavy-tailed inter-event time distribution at population level is well accepted, while whether the individual acts in a heterogeneous way is still under debate. Motivated by the impact of temporal heterogeneity of human activities on epidemic spreading, this paper studies the susceptible-infected model on a fu...

Recent research has identified the heterogeneity as crucial for the evolution of cooperation in spatial population. However, the influence of heterogeneous noise is still lack. Inspired by this interesting question, in this work, we try to incorporate heterogeneous noise into the evaluation of utility, where only a proportion of population possesses noise, whose range can also be tuned. We find...