Hyperdiploidy with greater than or equal to 50 chromosomes is a frequent and distinct karyotypic pattern in the malignant cells of children with acute lymphoblastic leukemia. To understand better the mechanism of formation of the hyperdiploid karyotype, we studied 15 patients using 20 DNA probes that detect restriction fragment length polymorphisms. We first examined disomic chromosomes for los...

Mathematical formulae for the sampling variances of average heterozygosity and NEI'S genetic distance are developed. These sampling variances are decomposed into their two components, i.e. the inter-locus and intra-locus variances. The relationship between the number of loci and the number of individuals per locus to be examined for estimating average heterozygosity and genetic distance is also...

The genetic diversity and differentiation of three Chinese Bruguiera gymnorrhiza populations was examined in this study: Expected heterozygosity at species and population levels was 0.293 and 0.268, observed heterozygosity was 0.2745 and 0.2705, respectively. The genetic diversity between populations was 0.0830, which showed that among total heterozygosity, 8.3% came from inter-population. Gene...

The melanocortin-1 receptor (MC1R) gene has been investigated by many studies regarding the pigmentation variation in various species. In order to determine its allelic and genotypic distribution, we sequenced the goat MC1R gene from 78 individuals in ten populations (Gembrong, Senduro, Ettawa Grade, Boerawa, Boerka, Kosta, Samosir, Muara, Boer and Kacang). Direct sequencing m...

We investigated the link between heterozygosity and the reaction norm attributes of reproductive performance in female house sparrows (Passer domesticus). We collected data on clutch size, egg size, hatching success and nestling survival in 2816 nesting attempts made by 791 marked individuals over a 16-year period. Pedigree analysis revealed no evidence of inbreeding. Neither parent-offspring r...

Case presentation: Boy, 10 months, late premature infant. His parents aren’t consanguineous. He had recurrent and refractory spasm-like seizures, neurodevelopmental regression started at 4 months. On physical examination, he lack of visual social interaction, microcephaly, central hypotonia, upper motor neuron syndrome dyskinesias. seizure control with Levetiracetam for just one month. It was i...

Loss of heterozygosity occurring on various chromosomes has been described in the majority of human tumors. The targets of frequent or consistent subchromosomal deletions are believed to be tumor suppressor genes. We examined 72 esophageal tumors (46 squamous cell carcinomas and 26 adenocarcinomas) for loss of heterozygosity at the p53, Rb, APC, MCC, and DCC loci. Inclusion of these tumor suppr...