Chiral oxazoline based bi and hexadentate ligands built on cyclophosphazene cores have been synthesized and characterized. (NPPh2)2[NP(m-OC6H4C(O)OCH3)2] (1) was prepared by the reaction of gem-(NPPh2)2(NPCl2) with methyl-3-hydroxy benzoate in the presence of Cs2CO3. Compound 1 was converted to the dicarboxylic acid (NPPh2)2[NP(m-OC6H4C(O)OH)2] (2) by base promoted hydrolysis with KO(t-Bu). The...

Transient hydride ligands bridging two or more iron centers purportedly accumulate on the iron−molybdenum cofactor (FeMoco) of nitrogenase, and their role in the reduction of N2 to NH3 is unknown. One role of these ligands may be to facilitate N2 coordination at an iron site of FeMoco. Herein, we consider this hypothesis and describe the preparation of a series of diiron complexes supported by ...

The use of GdIII complexes as contrast agents in magnetic resonance imaging (MRI) has proven invaluable in the diagnosis of several internal abnormalities.1 The range of medical applications for which contrast agents are useful is likely to increase in the future with the development of target-specific contrast agents of increased relaxivity, such as MS-325 which binds with HSA in the blood poo...

Iron deficiency affects 500 million people, yet the molecular role of iron in gene expression remains poorly characterized. In addition, the alterations in global gene expression after iron chelation remain unclear and are important to assess for understanding the molecular pathology of iron deficiency and the biological effects of chelators. Considering this, we assessed the effect on whole ge...

Complexes of the type [MCl2(7-nitro-1,3,5-triaza-adamantane)2] (M = Zn(II), Pd(II), Pt(II)) and [MCl2(H2O)2(7-nitro-1,3,5-triazaadamantane)2] (M = Mn (II), Co(II), Ni(II)) have been prepared and their structures have been analysed by X-ray crystallography, elemental analysis, IR and solid state C and N NMR spectroscopy, supported by density functional theory/gauge independent atomic orbital (DF...