Mucin is the main constituent of gastrointestinal mucus and is responsible for its physicochemical and physiological properties. Previous studies have suggested that this glycoprotein represents a major component of undigested endogenous protein at the ileum. The aim of the study was to estimate the ileal output of this glycoprotein using three methods: direct ELISA, hexosamine-based method and...

Variations of serum sialic acid and total hexosamine ( glucosamine and gala· ctosamine) levels were investigated in rats of the Sprague-Dawley strain for clarification as follows: ( 1) Physiological variations of these levels by age in normal rats. (2) Variations of these levels during the growth of tumor after intramedullar implantation of Walker carcinosarcoma 256; relationship between these ...

Studies on hyaluronate in normal human synovial fluid have been hindered by the high viscosity and small volume of fluid available. Reports on hyaluronate levels in normal synovial fluid, in which a number of different methods have been used, have shown discordant results (1-4). Several methods were used in the present study to determine the hyaluronate content of normal synovial fluid. Weighin...

The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated β-catenin degradation. This results in the accumulation and subsequent nuclear translocation of β-catenin, which induces the expression of a number of genes involved in growth, differentiation and metabolism. The mechanisms regulating the Wnt signalling pathway in the physiological context is still not fully und...