1. A description is given of the isolation of a glycoprotein from hen's-egg white; it has been called ovoglycoprotein. 2. It contains 13.6% of hexose, 13.8% of hexosamine and 3% of sialic acid. 3. Hexose occurs as mannose and galactose in the ratio 2:1, hexosamine as glucosamine and sialic acid as N-acetylneuraminic acid. 4. It has S(20,w) 2.47s and a minimum molecular weight, calculated from t...

During the course of investigations on the metabolism of hexosamines in animal tissues, absorption spectra of the color produced in the hexosamine method of Elson and Morgan (1) revealed the presence of interfering chromogens. Similar types of interference have been noted in studies on the jelly coat of sea-urchin eggs (2), Neurospora (3), and pineapple plants (4). Hexosamines were found to pro...

Background: Diabetes mellitus (DM) is a metabolic disorder that characterized by hyperglycemia and glucose intolerance, which associated with impaired insulin secretion peripheral sensitivity eventual b-cell dysfunction. This review summarized the major pathways leading to both microvascular macrovascular complications in DM, view of highlighting enzymes involved possible inhibition facilitatin...

The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the HBP in metabolism and multiple diseases, regulation of the HBP remains largely undefined. Here, we show that spliced X-box binding protein 1 (Xbp1s), the most conserved signal trans...

The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 (GNPNAT1) is found to be significantly decreased in CRPC co...