Purpose: We demonstrate that meaningful cross-sectional differences in the subfields of the hippocampal formation (HF) can be detected in patients with mild cognitive impairment (MCI) using automatic segmentation of focal T2-weighted MRI. Boundaries between the layers and subfields of the HF are virtually indistinguishable in routine 1 mm T1-weighted MRI at 1.5 and 3 Tesla. However, mounting ev...

[Editor’s note: We goofed! The transmission of telephony in digital format (emission designator J1E or J2E) is perfectly legal in the phone bands. The restriction placed on transmitted baud rate by §97.307(f)(3) of the FCC rules does not apply. In fact, there is no upper limit on the bit rate for this mode. See the sidebar by ARRL Technical Relations Manager Paul Rinaldo, W4RI. Some of this mat...

High-fat (HF)-diet rodent models have contributed significantly to the analysis of the pathophysiology of the insulin resistance syndrome, but their phenotype varies distinctly between different studies. Here, we have systematically compared the metabolic and molecular effects of different HF with varying fatty acid compositions. Male Wistar rats were fed HF diets (42% energy; fat sources: HF-L...

Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen-anagen transition (TAT) around the wound and de novo HF regeneration, mostly through TNF signalling. Both TNF knockout and overexpression attenuate HF neogenesis in wounds, suggesti...

BACKGROUND Myocardial infarction increases the risk of heart failure (HF) and atrial fibrillation. Renal denervation (RDN) might suppress the development of atrial remodeling. This study aimed to elucidate the molecular mechanism of RDN in the suppression of atrial fibrillation in a HF model after myocardial infarction. METHODS AND RESULTS HF rabbits were created 4 weeks after coronary ligati...

High-fat (HF) diets impair skeletal muscle response to the insulin-sensitizing adipokine adiponectin (Ad) in rodents, preceding the development of insulin resistance. Skeletal muscle insulin response in HF-fed rats can be restored with chronic exercise; whether recovery of skeletal muscle Ad response is necessary for the exercise-induced recovery of insulin-stimulated glucose transport is not k...

BACKGROUND Multidisciplinary heart failure (HF) clinics are efficacious in clinical trials. Our objectives were to compare real-world outcomes of patients with HF treated in HF clinics versus usual therapy and identify HF clinic features associated with improved outcomes. METHODS AND RESULTS The service components at all HF clinics in Ontario, Canada, were quantified using a validated instrum...