background: dendritic cells (dcs) are professional antigen presenting cells that have an important role in the initiation of immune response. the use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. objective: in this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and cpg oligonucleotides in inducing d...

background: tumor necrosis factor alpha (tnf-α) is a primary mediator of immune regulation and might be required in the early stages of dc development from cd34+ cells. however, details of optimal timing of exposure to tnf-α in dc development process in monocytes or non-purified hematopoitic cells are still lacking and clear benefits of this approach to the development of dcs remain to be valid...

background: infertility is an increasing medical and social problem. in vitro fertilization (ivf) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. natural killer (nk) cells have been identified as relevant immunological factors involved in reproductive success or failure. objective: the aim of this study was to compare the percentage of...

background micrornas are small and non-coding rna molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mrna. mir-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. one of its best known functions is apoptosis that affects on caspase-3 activity. the main aim ...

background: acyclovir (acv), a synthetic purine nucleoside analogue, is known to be toxic to gonads. objective: the current study evaluated cytotoxicity of acv on histopathological changes in testis tissue and serum testosterone and lipid peroxidation concentrations of male rats. materials and methods: animals were divided into five groups. one group served as control and one group served as co...

objective: doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose)exhibits potent antioxidant activity. so, in this study, we explored the protective effect...

objective: curcumin, is the active component in turmeric (curcuma long). this agent induces apoptosis via inhibiting various signaling pathways. however, its poor aqueous solubility prevents its widespread application. in this study, dendrosomes with water-solubility, nano-sized dimensions and nontoxic properties, was used for curcumin delivery to cells. materials & methods: in the present...

dead yeast cells are an abundant residue of the brazilian ethanol industry and the industries still don’t have a proper or desirable destiny for all these cells, which means tons of vitamins and proteins that have not a major end. in the other hand, heavy metal residues are a problem, especially for leather industry, where brazil is also a great producer. in this work, dead yeast cells were use...

introduction: spinal cord injuries (sci) lead to permanent irreversible functional deficits.  poor prognosis of patients is the motivation of searching a treatment for the chronic injury.  planting stem cells provides us with a promising strategy. in the meanwhile, the use of olfactory ensheathing cells (oecs) has shown very good results.  this study aims at evaluating the effect of transplante...

to follow-up the present study, 40 mature female rats were used. the animals were divided into test,control and sham groups. the rats in the test group were laparotomized and unilateral ovariectomy was done. on the 1st and 2nd met-oestrous after operation, the tissue samples were dissected out and processed for histological study. the intact ovary in the test group underwent a significant (p