Concerns pertaining to the risk of estrogen exposure through HT have prompted an increase in the use of natural alternatives. Phytoestrogens may provide postmenopausal women with a practical alternative and many women have already begun to utilize phytoestrogen supplements. However, research regarding the efficacy of phytoestrogens as a hormone therapy alternative has been previously pessimisti...

During obesity, excess body weight is not only associated with an increased risk of type 2-diabetes, but also several other pathological processes, such as infertility. Adipose tissue the largest endocrine organ that produces adipokines, including adiponectin. Adiponectin has been reported to control fertility through hypothalamic–pituitary–gonadal axis, and folliculogenesis in ovaries. In this...

Genistein is one of non-steroidal phytoestrogens present in soya and soybean products as well as in other legumes. Phytoestrogens possess estrogen-like biological activity and may influence human and animal reproduction. The aim of this study was to examine the effect of genistein on testosterone (T) secretion by isolated Leydig cells in roosters. Genistein (5-50 microM) inhibited (p<0.05) in v...

The review highlights current views and hypotheses on the pathogenetic role of natural xenoestrogens in disorders programming neuroendocrine regulation reproduction, alaptation, various forms instinctive behavior (reproductive, eating, parental, etc.) perinatal period development female brain. Catecholestrogens, which are formed brain as a result sequential metabolic conversions testosterone, i...

Impressive data from the many studies on cultured bone cells and rat models of postmenopausal osteoporosis support a significant bone-sparing effect of the soy isoflavones genistein and daidzein. Translating this research to the clinic has been more challenging, and thus far only a few clinical studies have attempted to tease out the influence of phytoestrogens on bone from the many other compo...

Phytoestrogens are estrogen-like chemicals found in plant foods such as beans, seeds, and grains. Foods made from soybeans have some of the highest levels of phytoestrogens and have been studied the most. In spite of initial optimism, it is not clear whether eating foods rich in phytoestrogens decreases breast cancer risk. This is an active area of research with much work needed to resolve this...

Osteoblasts are critical in bone remodeling and the repair of bone fractures. Leptin is involved in bone metabolism and osteoblast survival through the downstream signaling pathway, however, the exact mechanism of the effect of leptin on osteoblasts remains to be fully elucidated. In the present study, hFOB 1.19 cells were used to observe the effects of leptin on cell proliferation and apoptosi...

Hormone-dependent cancers contribute to the majority of cancer deaths in women. Treatment options for hormonal such as breast, endometrial, prostate, and ovarian aim at inhibiting key signalling pathways hormones responsible cell proliferation. Hormonal therapies long run cause musculoskeletal disorders, Disease reoccurrence, drug resistance. There is a need new alternative prevent treat carcin...

We investigated the estrogenic activity of various environmental pollutants (xenobiotics), in particular the xenoestrogen o,p-DDT, and compared their effects with those of endogenous estrogens, phytoestrogens, and mycoestrogens on estrogen receptor binding capacity, induction of estrogen end products, and activation of cell proliferation in estrogen-sensitive human breast cancer cells in monola...