Although hypertrophic cardiomyopathy (HCM) is genetically determined, several other factors, including autonomic dysfunction, may play a role in the phenotypic expression. A recent study using positron emission tomography with [11C]CGP 12177 ([11C]CGP) demonstrated that beta-adrenoceptor (betaAR) density is reduced in HCM and is correlated with disease progression. This present study tested the...

Direct laser acceleration (DLA) of electrons in a plasma near-critical electron density (NCD) and the associated synchrotron-like radiation are discussed for moderate relativistic intensity (normalized amplitude a0 ≤ 4.3) ps length pulse. This regime is typical kJ PW-class facilities designed high-energy-density (HED) research. In experiments at PHELIX facility, it has been demonstrated that in...

OBJECTIVES The aim of this study was to determine whether (11)C-hydroxyephedrine ((11)C-HED) can predict adverse events including all-cause death in Japanese patients with left ventricular (LV) dysfunction. BACKGROUND Although (11)C-HED PET has been used to assess cardiac sympathetic innervation in various disease conditions, data on their prognostic value are limited. METHODS Sixty patient...

OBJECTIVES Regional presynaptic sympathetic innervation varies considerably in the cardiomyopathic human heart, as shown in previous studies in vivo and in vitro. The goal of the present study was to correlate markers of presynaptic sympathetic innervation with local measurement of the postsynaptic beta-adrenergic system in failing human hearts. METHODS AND RESULTS In nine left ventricular re...

LLE Review, Volume 111 154 Introduction In the last 15 years, there has been considerable interest in experiments that use laser-driven shock waves to measure high-energy-density equation-of-state (HED-EOS) data.1–5 During this time, the generation of laser-driven shock waves has been refined, and the accuracy of the techniques employed has been improved significantly. Highly accurate optical s...

UNLABELLED The sympathetic nervous system of the heart plays a key role in the pathophysiology of various cardiac diseases. Small-animal models are valuable for obtaining further insight into mechanisms of cardiac disease and therapy. To determine the translational potential of cardiac neuronal imaging from rodents to humans, we characterized the rat sympathetic nervous system using 3 radiotrac...

Heavy episodic drinking (HED) is a major health problem for young adults. Rates of HED have remained consistently high among young adults for the past two decades. Though research has identified various intrapersonal, interpersonal, and environmental contributors to HED, the majority of research focuses on intrapersonal factors. As such, more research is needed to test the role that specific in...

Inertial confinement fusion (ICF) and high-energy density (HED) physics experiments experience complicated forcing for instability growth mix due to the ubiquitous presence of multiple shocks interacting with perturbations on material interfaces. One common driver is successive from same direction. However, there a severe lack analytic work modeling validation same-sided since they are extremel...

OBJECTIVE To evaluate the incidence of risky consumption (RC) and heavy episodic drinking (HED) in the Cohort of Spanish university students at two-year follow-up and to identify predictors of these patterns of alcohol consumption and the association between these patterns and academic achievement. METHOD We carried out a cohort study. Alcohol consumption was measured with the AUDIT. The foll...

This contribution presents numerical simulations of two recent High Energy Density (HED) physics experiments carried out at the GSI HHT experimental area using the SIS18 uranium beam. In one experiment, a solid lead target has been used while in the other case, a solid tungsten target has been considered. Our simulations show that with the existing beam parameters, one can achieve critical temp...