The acid-mediated tumor invasion hypothesis proposes altered glucose metabolism and increased glucose uptake, observed in the vast majority of clinical cancers by fluorodeoxyglucose-positron emission tomography, are critical for development of the invasive phenotype. In this model, increased acid production due to altered glucose metabolism serves as a key intermediate by producing H(+) flow al...

All mutants at 3 loci in Arabidopsis thaliana (L.) Heynh., a higher plant, that are associated with the synthesis or coupling of the thiazole moiety of thiamine are susceptible to reversible glucose inhibition. In contrast, several different alleles involved in the synthesis of the pyrimidine moiety of the vitamin are insensitive to glucose. Glucose and maltose are equally effective inhibitors ...

Tight regulation of fatty acid metabolism in pancreatic -cells is important for -cell viability and function. Chronic exposure to elevated concentrations of fatty acid is associated with -cell lipotoxicity. Glucose is known to repress fatty acid oxidation and hence to augment the toxicity of fatty acids. The peroxisome proliferator activated receptor (PPAR ) is a key activator of genes involved...

AIMS Exposure to high glucose (HG) stimulates reactive oxygen species (ROS) production by NADPH oxidase in cardiomyocytes, but the underlying mechanism remains elusive. In this study, we have dissected the link between glucose transport and metabolism and NADPH oxidase activation under hyperglycaemic conditions. METHODS AND RESULTS Primary cultures of adult rat cardiomyocytes were exposed to ...

Diabetes is a disease in which premature development of conditions which increase blood coagulation are the leading cause of death. A reduction in the consequences of elevated glucose levels is the main focus of clinical treatment. It has been determined that the addition of glucose to anti-coagulated human blood, followed by incubation for 24 hours results in the generation of a hypercoagulabl...

Background and objective. Beta-blocker overdose may result in intractable cardiovascular collapse despite conventional antidotal treatments. High dose insulin/glucose (ING), and more recently intravenous lipid emulsion (ILE), have been proposed as potentially beneficial therapies in beta blocker intoxication. We compare efficacy of the novel antidotes ING, with ILE, in a rabbit model of combine...

Background: Quantum dots are commonly composed of cadmium contained semiconductors. Cadmium is potentially hazardous but toxicity of such quantum dots is not yet systematically investigated. On the other hand, in vitro studies have shown almost complete control of CdSe induced cytotoxicity by ZnS coverage. Toxicity of CdSe quantum dots and controlling this toxicity by ZnS coverage in immature m...

Abstract: Background: Ajos sacha is a shrubby herb and has attracted scientists’ attention due to its antioxidative, antineoplastic, larvicidal, antibacterial properties. Hence, assessed in vitro vivo diabetes protective Materials Methods: The methodology started with the quantitative phytochemical estimation of ethanolic extract Adenocalymma alliaceum (EEAA). Then, was studied for cytotoxicity...

Drug-induced human hepatotoxicity is difficult to predict using the current in vitro systems. In this study, long-term 3D organotypic cultures of the human hepatoma HepaRG cell line were prepared using a high-throughput hanging drop method. The organotypic cultures were maintained for 3 weeks and assessed for (1) liver specific functions, including phase I enzyme and transporter activities, (2)...