Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is associated with extended lifespan in simple animals and a reduced incidence o...

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that respond to several exogenous and endogenous ligands by modulating genes related to lipid, glucose, and insulin homeostasis. PPARγ, expressed in adipose tissue and liver, regulates lipid storage and glucose metabolism and is the target of type 2 diabetes drugs, thiazolidinediones (TZDs). Due to high l...

Initial treatment included 100 ml 50% glucose i.v., oxygen at 10 l/min and when his conscious level toxicity improved, a gastric lavage. His conscious level returned to 15/15 on the GCS. Blood glucose was measured at 18 mmol/l.

essential oil of rosmarinus officinallis was investigated on toxicity and physiological aspect of elm leaf beetle xanthogaleruca luteola mull. for 3rd instar larvae and adults in controlled condition (25 ± 2 °c; 14:10ld; 65% rh). lc50 were estimated 2.55 and 1.11 for 3rd instar larvae and adults respectively. the effect of lc50 dose on remaining insects were investigated on nutritional indices....

Introduction : Satureja montana is a wild growing medicinal plant, part of the Lamiaceae family. This herb well known as source phenolic compounds, which can vary in broad range depending on different factors and exert many pharmacological activities. Aim The aim study was to investigate composition chronic toxicity dry extract . Material methods investigated by high-performance liquid chromato...

Aluminum (Al) toxicity is the primary factor limiting agricultural productivity in acid soils. The cell wall mainly composed of saccharides and first barrier for aluminum to enter plant root cells, but it unknown whether how saccharide components are involved regulating Al tolerance Lespedeza that well adapted Here, we used Al-tolerant bicolor Al-sensitive cuneata examine association with throu...

T2DM (Type 2 diabetes) is a complex, chronic disease characterized as insulin resistance and islet β-cell dysfunction. Bariatric surgeries such Roux-en-Y gastric bypass (RYGB) surgery laparoscopic sleeve gastrectomy (LSG) have become part of critical treatment regimen in the obesity T2DM. Moreover, GLP-1 increase following bariatric has been regarded significant event surgery-induced remission ...

introduction: g-proteins have an important role in the cell signaling of numerous receptors. the situation of g-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. here, the changes in the expression of g-protein subunits (gαi, gαs and gβ) were evaluated in hyperglycemic situation of pc12 cells as a cellular model...