different treatment strategies of alzheimer's disease (ad) are being studied for treating or slowing the progression of ad. many pharmaceutically important regulation systems operate through proteins as drug targets. here, we investigate the drug target proteins in beta-amyloid (aβ) injected rat hippocampus treated with lavandula angustifolia (la) by proteomics techniques. the reported stu...

objective: oxidative stress plays an important role in the etiology of diabetic complications. diabetes impairs hippocampus neurogenesis, synaptic plasticity, and learning. the aim of this study was to investigate the effects of hydroalcoholic extract of nigella sativa seed on oxidative stress in stz-induced diabetic rats' hippocampus. materials and methods: diabetes induced by 60 mg/kg st...

ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...

how to cite this article: saeedi borujeni mj, hami j, haghir h, rastin m, sazegargh. evaluation of bax and bcl-2 proteins expression in the rat hippocampus due to childhood febrile seizure. iran j child neurol. winter 2016; 10(1):53-60. abstract objective simple febrile seizure (sfs) is the most common seizure disorder in childhood, and is frequently described as inoffensive disorder. neverthel...

objective(s) the aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (stz)-induced diabetic rat. materials and methods a total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). diabetes was induced by injection of single dose of stz. exercise was...

results in all groups ischemic changes were apparently observed in hippocampus ca1 neurons. in two-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 14.9% and 23.2%, respectively. in four-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 7.6% and 44.9% (p < 0.0001), respectively. background an appropriate animal m...

The cover image is based on the Editorial Adult neurogenesis in hippocampus by Gerd Kempermann et al., https://doi.org/10.1002/hipo.23525.

EFFECT OF 6 WEEKS ENDURANCE TRAINING WITH QUERCETIN SUPPLEMENTATION ON THE EXPRESSION MITOCHONDRIAL PGC-1Α AND ATF2 GENES IN HIPPOCAMPUS DIABETIC MALE RATS