Background Aluminum (Al) is known to induce neurotoxicity in both humans and rodents. Recent evidence has indicated that the toxicity of Al Oxide (Al2O3) Nanoparticles (Al-NP), one most abundantly used engineered nanoparticles, far greater than itself. To date, however, no information available regarding effect Al-NP on stereological parameters hippocampus. In particular, studies have evaluated...

The G9a/G9a-like protein (GLP) histone lysine dimethyltransferase complex and downstream H3 9 dimethylation (H3K9me2) repressive mark have recently emerged as key transcriptional regulators of gene expression programs necessary for long-term memory (LTM) formation in the dorsal hippocampus. However, role hippocampal G9a/GLP mediating consolidation spatial LTM remains largely unknown. Using a wa...

Abstract Retinoic acid (RA), a metabolite of vitamin A, has many physiological functions, and mounting evidence points to important roles in cognition. In vitro experiments indicate that RA is involved homeostatic synaptic scaling the hippocampus, which supports overall network stability during learning. It been previously determined disrupted signaling hippocampus causes deterioration memory, ...

Introduction Porphyromonas gingivalis ( P. ), a major periodontal pathogen, causes intrauterine infection/inflammation. Offspring exposed to infection/inflammation have an increased risk of neurological disorders, regardless gestational age. However, the relationship between maternal periodontitis and offspring functional/histological changes in brain has not yet been elucidated. Methods In thi...

Investigation of the Role L-Arginine and L-NAME in Dorsal Hippocampus on Anxiety, Depression Brain Level BDNF after Stress Male Mice

To investigate emotion recognition in amyotrophic lateral sclerosis (ALS) patients without cognitive/behavioral deficits and its relationship with the integrity of basal ganglia, hippocampus amygdala.

Abstract Erythropoietin (EPO) improves neuronal mitochondrial function and cognition in adults after brain injury those afflicted by psychiatric disorders. However, the influence of EPO on mitochondria during development remains unexplored. We previously observed that stimulates hippocampal-specific maturation synaptogenesis early postnatal mice. Here we show promotes respiration developing hip...

objective: oxygen free radicals may be implicated in the pathogenesis of ischemia reperfusion damage. the beneficial effects of antioxidant nutrients, as well as complex plant extracts, on cerebral ischemia-reperfusion injuries are well known. this study was conducted to determine the effects of the hydro-alcoholic root extract of withania coagulans on ca1 hippocampus oxidative damages followin...