The basis for a robust and accurate quantification is the segmentation of regions of interest (ROIs) defined by different histopathologic features. Several kinds of problems arise in ROIs segmentation of histopathologic images due to diverse factors such as: nonstationary and correlated noise, illumination, busyness of gray levels within the object and its background, inadequate contrast, among...

BACKGROUND AND PURPOSE Imaging methods are currently being optimized in an attempt to assess and monitor angiogenesis in vivo. The purpose of this investigation was to determine whether areas of apparently increased tumor vascularity, as identified on 8-T gradient-echo (GE) imaging of a known glioblastoma multiforme (GBM), corresponds to foci of increased microvascularity on histopathologic ana...