Interleukin-12 (IL-12), a cytokine with in vitro and in vivo immunomodulatory effects, is produced mostly by activated monocytes and macrophages. To study the effect of human immunodeficiency virus (HIV) infection on IL-12 production, we investigated the expression of IL-12 at mRNA and protein levels by human monocytes preincubated with HIV-gp120. In these conditions, we show that monocytes hav...

In the present study, we newly synthesized three types of novel fullerene derivatives: pyridinium-type derivatives trans-3a and 4a-5b, piperidinium-type derivative 9, proline-type 10a-12. Among assessed compounds, 5a, 10e, 10f, 10i, 11a-d, 12 were found to inhibit both HIV reverse transcriptase protease (HIV-PR), with IC50 values in low micromolar range being observed. Regarding HIV-PR inhibiti...

Abstract HIV self-disclosure is an important challenge affecting the physical and psychological health of adolescents living with HIV. The study’s aim was to explore perspectives HIV-infected on self-disclosure. Using purposive sampling, 20 aged 12–19 years were recruited from a care clinic at tertiary hospital in Harare, Zimbabwe. All vertically-infected (HIV transmitted mother). In depth inte...

The objective: to evaluate immediate and postponed results of surgical treatment tuberculosis (TB) in patients with TB/HIV co-infection. Subjects methods. 106 underwent surgery: 64 suffering from pulmonary (81.2% had resections, 18.8% – thoracoplasty), 36 tuberculous spondylitis (vertebral body resection combination anterior spondylodesis), 6 cerebral TB (removal lesions under neuronavigation)....

Abstract Cryptococcal meningitis (CM) is the most fatal adult in patients with human immunodeficiency virus (HIV). There no conclusive evidence for superiority of 1-week amphotericin B deoxycholate (AmphB) + flucytosine (5-FC) regimen over other antifungals management HIV CM (HIV–CM patients). We aimed to evaluate differences efficacy and tolerability different antifungal agents HIV–CM by condu...

"Globally, 35 million people are infected with HIV, and this population is at a higher risk of developing cancer. We reporting the case 44-year-old HIV-positive male patient. He smokes drinks occasionally, but he otherwise in good health. was diagnosed visceral form Kaposi sarcoma January 2022 has undergone 12 cycles oncologic treatment liposomal doxorubicin our facility."

Background and Purpose: Candida species are the common opportunistic pathogens during the course of human immunodeficiency virus (HIV) infection. Oropharyngeal candidiasis (OPC) is generally known as the initial sign of HIV infection. The aim of this study was to compare demographic characteristics and frequency of Candida species between HIV/AIDS patients and non-HIV subjects in Kerman, southe...

Cytokines may have clinical utility as therapeutic agents for human immunodeficiency virus type 1 (HIV-1) infection and as an adjuvant for vaccines. The effect of interleukin-12 (IL-12) and IL-15 on in vitro HIV-1 replication was investigated. IL-12 and IL-15 at doses up to 10 ng/ml had little effect on basal HIV-1 p24 antigen production by chronically HIV-infected T (ACH-2) and monocytic (U1) ...