Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...

background drug design against human immunodeficiency virus type 1 (hiv-1) integrase through its mechanistic study is of great interest in the area in biological research. the main obstacle in this area is the absence of the full-length crystal structure for hiv-1 integrase to be used as a model. a complete structure, similar to hiv-1 of a prototype foamy virus integrase in complex with dna, in...

objective: in this study, a sybr green real-time rt-pcr assay for quantification of hiv-1 viral rna was developed. materials and methods: this assay was performed based on amplification of the pol region of hiv-1 and product analysis by an abi 7500 system. we quantified hiv-1 viral load in 26 seropositive patients by this system and the data were subsequently compared with results obtained wit...

Early diagnosis of Human immunodeficiency virus (HIV) in infants provides a critical opportunity to strengthen follow-up HIV- exposed children using dried blood spots and assure early access antiretroviral treatment for infected children. This study aimed determine the prevalence HVI-1 infection born HIV-seropositive mothers. infant HIV sub-type I was carried out on 286 babies HIV-I seropositiv...

developed in 1991, nucleic acid sequence-based amplification (nasba) has been introduced as a rapid molecular diagnostic technique, where it has been shown to give quicker results than pcr, and it can also be more sensitive. this paper describes the development of a molecular beacon-based multiplex nasba assay for simultaneous detection of hiv-1 and hcv in plasma samples.a well-conserved region...