Objective. Substances such as inositol and N-acetylcysteine (NAC) have been recently shown to be effective in treatment of PCOS patients. The aim of this prospective trial is to evaluate the efficacy of NAC + Inositol + folic acid on ovulation rate and menstrual regularity in PCOS patients with and without insulin resistance. Methods. Among the 91 PCOS patients treated with NAC + Inositol + fol...

Purpose. To evaluate glucose and insulin profiles in adolescents with mild stunting and overweight in order to assess the possibility of increased predisposition to diabetes. Subjects and Methods. The study population consisted of 66 pubertal adolescents classified as mildly stunted (height-for-age z scores ≥-2 and <-1) or of normal stature, as well as overweight (body mass index ≥85th percenti...

RESEARCH DESIGN AND METHODSdOne-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement Program in Chennai, India, had a 75-g oral glucose tolerance test, with glucose and insulinmeasured at 0, 30, and 120min. Type 2 diabetes, isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT), combined impaired fasting...

Objectives This study was aimed to investigate the effect of Berberis integerrima (B. integerrima) extract on insulin sensitivity in high-fructose-fed insulin-resistant rats. Materials and Methods Experimental rats were randomly divided into two groups: the control group was fed a regular chow diet while other group fed with a high-fructose diet for 8 weeks. After the first six weeks, the ani...

OBJECTIVE We sought to examine the distribution of insulin and homeostasis model assessment of insulin resistance (HOMA-IR) and associations of HOMA-IR with sex, race/ethnicity, age, and weight status, as measured by BMI, among U.S. adolescents. RESEARCH DESIGN AND METHODS Of 4,902 adolescents aged 12-19 years who participated in the National Health and Nutrition Examination Survey 1999-2002,...

BACKGROUND/AIMS Lipid profile and insulin resistance (IR) are associated with hepatitis C virus (HCV) and may predict the chronic hepatitis C (CHC) treatment response. The aim of this study was to determine the association between CHC treatment response and lipid profile and IR change during treatment. METHODS In total, 203 CHC patients were reviewed retrospectively between January 2005 and D...

BACKGROUND The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. OBJECTIVES To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR ind...

OBJECTIVE To investigate the effect of caloric restriction (CR) on expressions of peroxisome proliferators-activated receptors (PPARs) and positive transcription elongation factor b (P-TEFb) (including cyclin-dependent kinase 9 (CDK9) and cyclin T1) protein in visceral adipose tissue of obese rats. MATERIALS AND METHODS Obese rats were induced by high-fat diet for 8 weeks. Then they were divi...

Science is still searching for readily available, cost-effective biomarkers to assess metabolic disorders occurring before the onset and during development of type-2 diabetes (T2DM). The aim present study was induce T2DM in rats through a high-fat diet, followed by single administration low dose streptozotocin (STZ), make an assessment disease. were divided into two groups—experimental control—...

Objective: To evaluate correlation of leptinemia with components of Metabolic Syndrome (MetS) in Moroccan youths, and effect of obesity, Blood Pressure (BP), gender and puberty stage on MetS-components. Study design: Anthropomorphic, metabolic and clinical parameters [Body Mass Index (BMI), Waist Circumference (WC), energy intake, Blood Pressure (BP), Plasma levels of lipids, leptin, Alanine-Am...