TOPIC: Sleep Disorders TYPE: Original Investigations PURPOSE: disordered breathing (SDB) is common in pregnancy. A relationship has been described late pregnancy between SDB and abnormal glucose metabolism, gestational diabetes mellitus (GDM). However, it remains unclear whether this starts early or develops following exposure to pregnancy.The goal of the current study examine association its s...

BACKGROUND Drugs with unspecific stimulating effects on beta-cell secretion increase the homeostasis model assessment (HOMA)-B score, indicating improved beta-cell "function." We investigated whether the beta-cell protection provided by adding pioglitazone (PIO) to glimepiride (GLIM) in comparison to up-titrating the GLIM dose alone is reflected by appropriate changes in several measures of bet...

Adipose tissue-derived hormone leptin plays a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity which also represent the risk factors for nonalcoholic fatty liver disease (NAFLD). The present study explored the gender specific association of serum leptin and insulinemic indices with NAFLD in Bangladeshi prediabetic subjects. Under a cross-sect...

Background: Type 2 diabetes mellitus (T2DM) is non-insulin-dependent or that affects adults, and it represents 90% of diabetics occurs as a result insulin resistance defect in production. We aimed to evaluate levels adropin, insulin, lipid profile type2 patients.
 Aim: The current study investigate the relationship between type liver adipose tissue by measuring level secreted Hepatokines n...

OBJECTIVE To determine the association of insulin sensitivity and pancreatic beta-cell function parameters assessed by the homeostasis model assessment (HOMA) and glycemic control, and their potential utilization in the clinical care of patients with type 2 diabetes mellitus. MATERIAL AND METHOD The HOMA indices were assessed in 204 (62 males, 142 females) type 2 diabetic outpatients aged 60....

INTRODUCTION Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications. This study aimed to assess the effects that, nine months of pharmacological intervention with orlistat or sibutramine, on obese Malaysians' body weight and compositions, metabolic profiles and inflammatory marker. METHODS Seventy-six obese subjects were randomly placed in...

OBJECTIVE To compare the pathophysiology of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in a more comprehensive and standardized fashion than has hitherto been done. RESEARCH DESIGN AND METHODS We studied 21 individuals with isolated IFG (IFG/normal glucose tolerance [NGT]), 61 individuals with isolated IGT (normal fasting glucose [NFG]/IGT), and 240 healthy control su...

We performed a cross-sectional survey 1–5 years after 1,263 women who had GDM gave birth. Polytomous logistic regression models were used to assess the associations of b-cell dysfunction (the lower quartile of HOMA [%b]), insulin resistance (the upper quartile of HOMA-insulin resistance), decreased insulin sensitivity (the lower quartile of HOMA [%S]), and different categories of BMI with predi...

Background. To assess fasting C-peptide and insulin indices using homeostatic model assessment (HOMA) in gestational diabetes mellitus (GDM). Methods. Gestational (n = 64, age: 27.02 ± 0.53 years, BMI: 26.3 0.5 kg/m2; mean SEM) normal glucose tolerance NGT 56, 26.11 0.55 24.4 0.4 screened according to WHO 2013 criteria. Glucose was measured by oxidase method whereas ELISA. HOMA-IR, HOMA-B HOMA-...

BACKGROUND The present study aimed to determine the most efficient insulin resistance function related to glycemic control expressed as glycated hemoglobin (HbA1c) in type 2 diabetes mellitus patients (T2DM). The other aim is to derive equations for the prediction of beta cell functions containing HbA1c as a parameter in addition to fasting glucose and insulin. METHODS T2DM Patients were grou...