This paper presents an algorithm for combining pattern recognition-based exon prediction and database homology search in gene model construction. The goal is to use homologous genes or partial genes existing in the database as reference models while constructing (multiple) gene models from exon candidates predicted by pattern recognition methods. A unified framework for gene modeling is used fo...

Targeted therapy is a promising approach for treatment of neuroblastoma as evident from the large number of targeting agents employed in clinical practice today. In the absence of known crystal structures, researchers rely on homology modeling to construct template-based theoretical structures for drug design and testing. Here, we discuss three candidate cell surface proteins that are suitable ...

Collagen type XI is a quantitatively minor but developmentally essential component of the extracellular matrix and as a secreted protein is subject to a variety of posttranslational modifications. These modifications have been shown to influence the affinity of endogenous binding between collagen XI and various extracellular matrix components. The three dimensional structure of the amino termin...

Bacteriorhodopsin (bR) is a light-driven proton pump, which is a membrane protein with seven transmembrane helices and a prosthetic group of retinal. The structure of bR has been determined at high resolution, and the homology modeling of G-protein coupled receptors, which have seven transmembrane helices, is usually carried out based on the structure of bR as the structure template. However, t...