Objective(s):  Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing...

1. Abstract 2. Introduction 2.1. HPV infection and carcinogenesis 2.2. Major transforming activities 2.3. The HPV life cycle 3. Section 3. The HPV E7 protein 3.1. Cellular targets of HPV E7 proteins: the retinoblastoma protein family 3.2. Cellular targets of HPV E7 proteins: cyclin-dependent kinase inhibitors 3.3. Cellular targets of HPV E7 proteins: chromatin modifying factors 4. Section 4. Th...

Human papillomaviruses (HPV) may cause sexually transmitted disease. High-risk types of HPV are involved in the development of cervical cell dysplasia, whereas low-risk types may cause genital condyloma. Despite the association between HPV and cancer, donor sperm need not be tested for HPV according to European regulations. Consequently, the potential health risk of HPV transmission by donor ba...

The National HPV Immunization Programme, which offers free human papillomavirus (HPV) vaccines to teenaged female students, was launched in Malaysia in 2010. HPV vaccination paired with adequate knowledge about HPV infection provides the best protection against cervical cancer. To identify the level of knowledge and the health beliefs towards HPV and the HPV vaccine among HPV-vaccinated female ...

BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients wi...

OBJECTIVE To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group. MATERIAL AND METHOD Between 2006 and 2010, a total of 6388 patients' data was r...

Background, In this study, we sought to determine the prevalence, types, and maternal-fetal transmission of HPV in pregnant women in Nanjing, Jiangsu Province. Results, The overall cervical HPV-DNA positivity rate among pregnant women was 13.44% (422/3139). The most frequently detected HPV types in mothers were HPV-16 (29.62%, 125/422), HPV-18 (14.69%, 62/422), and HPV-58 (14.22%, 60/422). The ...

Further understanding of male human papillomavirus (HPV) infection is necessary to prevent infection in men, as well as transmission to women. In our current study, we investigated patterns of HPV infection and genotype distributions in male genital warts using the Anyplex II HPV28 Detection kit. We reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in Ulsa...