Breast cancer is a complex genetic disease that has an average annual incidence of two million people and the second leading cause of death among women all over the world. Micro-RNAs are consistently reported to regulate gene expression in all cancers. The present study, the correlation between the expression of hsa-miR-490-5p and nuclear factor of activated T-cells 5 (NFAT5) in breast cancer w...

Breast cancer is a serious health problem worldwide in women. MicroRNAs are small non-coding RNAs of 18–25 nucleotides in length that post-transcriptionally modulate gene expression. MiR-490 has been reported as a tumor suppressor and oncomiR microRNA in breast cancer with two separate targets, NFAT and Rho. NFAT is one of the targets for miR-490 but the relationship between hsa</e...

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role...

Introduction Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated polycystic ovary syndrome (PCOS) shown to affect microRNA (miRNA) expression. This work aimed determine if PCBs were circulating miRNAs whether there any correlations serum PCB/miRNA levels hormonal changes. Methods 29 non-obese PCOS healthy contr...

Introduction In gynecologic oncology, ovarian cancer is a great clinical challenge. Because of the lack typical symptoms and effective biomarkers for noninvasive screening, most patients develop advanced-stage by time diagnosis. MicroRNAs (miRNAs) are type non-coding RNA molecule that has been linked to human cancers. Specifying diagnostic determine non-cancer samples difficult. Methods By usin...

Aim: comparative analysis of the expression profile plasma microRNAs and target genes in patients with complicated pregnancy. Materials Methods. A prospective observational study parallel groups was carried out. The included 73 women divided into three groups: main group – 42 preeclampsia (PE), comparison 12 pregnant fetal growth retardation (FGR), control 19 clinically healthy uncomplicated An...

There is a need to determine the relationship between function of immune system and miRNA expression in pediatric celiac disease (pCD). We aimed describe profiles miRNAs Turkish pCD patients based on clinical pathological findings. This study was conducted 33 control subjects with normal biopsy results. Four most common mutations (DQA1*05, DQB1*02, DQA1*03, DQB1*03:0.2) HLA gene were screened. ...

Breast cancer is the second-most common cancer and second-leading cause of cancer mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in almost all cancers, including breast cancer. We comprehensively analyzed miRNA expression, global gene expression, and patient survival from the Cancer Genomes Atlas (TCGA) to identify clinically relevant miRNAs and their pote...