Cerebellins (CBLN1–4), together with C1qTNF proteins, belong to the CBLN subfamily of C1q proteins. Cerebellin-1 (CBLN1) is active in synapse formation and functions at parallel fiber-Purkinje cell synapses. form tripartite complexes neurexins glutamate-receptor-related proteins GluD1 GluD2, playing a role as trans-synaptic cell-adhesion molecules that critically contribute both functioning bra...

Parkinson's disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the disease. A loss of function parkin RING1 domain mutant (C289G) is associated with autosomal-recessive juvenile-onset Parkinsonism (AR-JP) and displays altered solubility and sequesters into aggregates. Single overexpression of almost each i...