Docetaxel (Taxotere, DTX) is a promoter of apoptosis in cancer cells. Since cytotoxic mechanisms of DTX are not yet fully understood, we have investigated the effects of DTX on apoptosis and ras-->Erk-mediated signal transduction in human epidermoid KB, colon HT-29 and breast HCC1937 cancer cells. We have found that the exposure to 0.78 or 1.56 or 2.5 ng/ml DTX for 48 h induced apoptosis and gr...

The HT-29 colon cancer cell line was used in the current work to investigate anti-cancer efficacy of Gymnema sylvestre extracts. viability, apoptosis, flow cytometry, and mode action active fraction were also evaluated. fractions G. caused cycle arrest at S phase G2/M phase, programmed death. alcoholic showed effect cells. By applying methanolic cells, IC50 observed 140.39 μg/mL, whereas for ch...