Although the primary cell cultures from dental pulp and other oral tissue are frequently used to study osteogenic potential and stem cell responses, few systematic and comparative studies on stemness for the dentinogenic differentiation of these cells have been conducted. In the present study, to investigate the stemness of oral primary cells during extended culture, human adult dental pulp cel...

stem cell therapy has been applied for the treatment of degenerative diseases encompassing corneal disorders.this consideration is regarding the unique characteristics of stem cells including self-renewal and pluripotency. some corneal diseases result from deficiencies in the limbal region. in these conditions, limbal stem cell therapy is considered in which limbal stem cells are cultured in vi...

Recent exciting discoveries place dentists at the forefront of engaging their patients in potentially life-saving therapies derived from a patient’s own stem cells located in deciduous and permanent teeth. Adult stem cells, including dental stem cells, have the potential, like bone marrow-derived stem cells and adipose-derived stem cells, to cure a number of diseases. In medicine, stem cell-bas...

SHED (stem cells from human exfoliated deciduous teeth) represent a population of postnatal stem cells capable of extensive proliferation and multipotential differentiation. Primary teeth may be an ideal source of postnatal stem cells to regenerate tooth structures and bone, and possibly to treat neural tissue injury or degenerative diseases. SHED are highly proliferative cells derived from an ...

A close cooperation between chromatin states, transcriptional modulation, and epigenetic modifications is required for establishing appropriate regulatory circuits underlying self-renewal and differentiation of adult and embryonic stem cells. A growing body of research has established that the epigenome topology provides a structural framework for engaging genes in the non-random chromosomal in...

BACKGROUND Successful pulp regeneration depends on identification of pulp stem cells capable of differentiation under odontoblastic lineage and producing pulp-dentinal like structure. Recent studies demonstrate that platelet-derived growth factor (PDGF) plays an important role in damage repair and tissue regeneration. The aim of this study was to identify a subpopulation of dental pulp cells re...

In recent years, stem cell research has grown exponentially owing to the recognition that stem cell-based therapies have the potential to improve the life of patients with conditions that range from Alzheimer's disease to cardiac ischemia and regenerative medicine, like bone or tooth loss. Based on their ability to rescue and/or repair injured tissue and partially restore organ function, multip...

Citation: Mitsiadis TA and Woloszyk A (2015) Odyssey of human dental pulp stem cells and their remarkable ability to survive in extremely adverse conditions. Front. Physiol. 6:99. Adult tissues contain stem cells, which proliferate to compensate for tissue loss throughout the life of the organism (Li and Clevers, 2010; Jiménez-Rojo et al., 2012). Therefore, adult stem cells are important for ti...