Background Patients can form antibodies to foreign human leukocyte antigen (HLA) Class I antigens after exposure allogeneic cells. These anti-HLA class bind transfused platelets (PLTs) and mediate their destruction, thus leading PLT refractoriness. with refractoriness need HLA-matched PLTs, which require expensive HLA typing of donors, antibody analyses patient sera and/or crossmatching. An alt...

Human leukocyte antigen (HLA) class I antigen defects may have a negative impact on the growing application of T-cell-based immunotherapeutic strategies for treatment of leukemia. Therefore in the present study, taking advantage of a large panel of HLA class I allele-specific human monoclonal antibodies, we have compared HLA class I antigen expression on leukemic cells with that on autologous a...

Immune checkpoint blockade is a compelling approach in tumor immunotherapy. Blocking inhibitory pathways T cells has demonstrated clinical efficacy different types of cancer and may hold potential to also stimulate innate immune responses. A novel emerging target for therapy leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1). LILRB1 belongs the superfamily receptors exerts fun...

Despite a number of controversies, the functional importance of human leukocyte antigen G (HLA-G) in early human pregnancy is now sustained by a large amount of sound data. Membrane-bound and soluble HLA-G isoforms, either as β2-microglobulin-free or -associated as monomers or dimers, are expressed by different trophoblast subpopulations, the only fetal-derived cells that are directly in contac...

background: human leukocyte antigen-e (hla-e)is a non-classical major histocompatibility complex (mhc) class i antigens which expressed on extra villous cytotrophoblast, which interacts with nkg2a, is an inhibitory receptor on natural killer (nk) cells and leading to down regulation of immune response in the maternal-fetal interface and provides maternal immune tolerance of the fetus. objective...

The past decade has seen human leukocyte antigen (HLA) typing emerge as a remarkably popular test for the diagnostic work-up of coeliac disease with high patient acceptance. Although limited in its positive predictive value for coeliac disease, the strong disease association with specific HLA genes imparts exceptional negative predictive value to HLA typing, enabling a negative result to exclud...

Background: Multiple sclerosis (MS), as a multifactorial autoimmune disease with complex genetic basis, causes demyelination in the central nervous system via cytokine responses to myelin antigens. Myelin basic protein (MBP) is the main protein component of the myelin sheath. HLA-DRB (human leukocyte antigen-DR beta) alleles, particularly HLA-DRB1*1501, may be of significance in the pathogenesi...

Background T cells recognize cancer cells via human leukocyte antigen (HLA)/peptide complexes, and class I HLA-restricted tumor infiltrating T lymphocytes correspond to favorable prognosis in several cancers, including ovarian cancer–the most deadly gynecologic disease [1]. The accurate identification of tumor-specific HLA/peptide complexes is pivotal to their exploitation as targets in immunot...

Description The genes of the Human Leukocyte Antigen (HLA) system reside on chromosome 6, and code for cellsurface proteins that play a crucial role in the presentation of endogenic peptides to effector cells of the immune system. The HLA Class I protein molecule is a heterodimer, made up of two chains; a heavy one and a light one (beta 2 microglobulin). The HLA-B gene is one of the three HLA C...

Background and Aims: In this study, the effect of rs310441 polymorphism in the human leukocyte antigen (HLA) region on the development of susceptibility or resistance to Type 1 diabetes (T1D) among the people with T1D compared to healthy subjects has been investigated. Materials and Methods: This research, which is based on the examination of 130 cases with T1D and 98 controls, has been carrie...