نتایج جستجو برای: human platelet antigens (hpa)
تعداد نتایج: 1779969 فیلتر نتایج به سال:
Abstract Background and Objectives Immune platelet refractoriness is a complication of blood transfusion in patients with multiple platelet transfusions. Antibodies against surface antigens, including human platelet antigens (HPAs) and human leukocyte antigens (HLAs), can be produced which can cause the degradation of transfused platelets by macrophages. In this study, the frequency of platele...
Abstract Background and Objectives Human platelet antigens (HPAs) are polymorphic structures located on the membrane of platelets (PLTs). These antigens have important role in clinical situations like refractoriness to platelet transfusion which is the most important cause of transfusion related mortality and morbidity in patients by recurrent platelet transfusion. Alloimmunization against the...
Background: Human platelet antigens (HPAs) are part of platelet GP complexes have the potential to contribute to the autoantibody production. Moreover, these antigens demonstrate different patterns of distribution on different ethnic groups and variation in some types of diseases. This study was objected to determine the incidence of HPA-1 to -5 and -15 polymorphisms in the Iranians suffering f...
ackground: knowing the human platelet antigens (hpa) and genes frequency in different populations is important not only for population studies but also for clinical transfusion practice. hpa genes frequency in iran is not evaluated, so we investigated the hpa-2, hpa-3, and hpa-5 frequency and their polymorphism. materials and methods: dna from 120 iranians (99 iranian blood donors and 21 patien...
Abstract Background and Objectives Following incompatible blood transfusions, anti-HLA and anti- HPA antibodies may develop and cause various disorders such as post-transfusion purpura, platelet refractoriness, and thrombocytopenia leading to bleeding. The aim of this study was to investigate platelet antigens and antibodies in multi-transfused patients. Materials and Methods In this desc...
ackground: Knowing the human platelet antigens (HPA) and genes frequency in different populations is important not only for population studies but also for clinical transfusion practice. HPA genes frequency in Iran is not evaluated, so we investigated the HPA-2, HPA-3, and HPA-5 frequency and their polymorphism. Materials and Methods: DNA from 120 Iranians (99 Iranian blood donors and 21 patie...
BACKGROUND Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The aim of this study was to investigate human platelet antigen frequencies in immune thrombocytopenia patients from the state of Amazonas, Brazil ...
Pregnancy-induced Alloimmunization against Platelet Antigens. HLA and Human Platelet Antigens (HPA).
Although platelet transfusion remains the standard therapy for the management of cases of extreme thrombocytopenia in neonatology, obstetrics, surgery, medicine and oncohematology, providing an indication and prescribing platelet transfusion remain subtle. The administration of platelets is often associated with many problems including their availability, cost, infectious risk and immunogenicit...
Abstract Background and Objectives Transfusion of platelet has become one of the main treatments for thrombocytopenic patients to reduce the severity and frequency of bleeding consequences. Failure to attain the desired level of platelets in a patient following platelet transfusion is defined as platelet refractoriness. The purpose of present paper is to review and study the mechanisms involve...
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