OBJECTIVES The goal of this study was to investigate the effects of ischemia-reperfusion on myocardial ultrastructure in patients with and without hibernating myocardium. BACKGROUND It is generally accepted that chronically dysfunctional, hibernating myocardium may remain nonetheless viable for a long time. It has been postulated that hibernating myocytes may survive, despite being subtended ...

background: this study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. methods: eighty male wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylactic and treatment control groups, groups 2 and ...

nitric oxide (no) is implicated as an important mediator of, or intermediary in, inflammation, immunity and neurotransmission. in the kidney, no is involved in haemodynamic regulation, control of vascular tone and tubular function. formation of oxygen-derived free radicals (ofr) have been documented in renal ischaemia- reperfusion before. in this study , we investigated the significance of no f...

objective(s):to investigate the effects of local mild hypothermia on the expression of fas, fasl and mmp-3 after cerebral ischemia-reperfusion in rats. materials and methods:male wistar rats were divided into sham-operated group (sham), normothermia group (nt), and hypothermia group (ht). mcao/r model was established by longa’s method, and reperfusion was allowed after 2 hr occlusion. mild hypo...

An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that result the blockage superior mesenteric artery (SMA) because significant clinical problems. This study evaluated effect Mesna on systemic induced by ischemia/reperfusion (IR) in also liver, kidney lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia...

Mitogen-activated protein kinases (MAPKs) have been shown to be activated in both in vitro and in vivo models of cardiac tissue in response to ischemia/reperfusion injury. We investigated whether MAPKs are activated in human heart during coronary artery bypass grafting (CABG) surgery. During elective CABG surgery of 8 patients, 3 right atrial appendage biopsies were obtained at baseline, at the...

Abstract Background and Aims Previous studies in chronic kidney disease (CKD) showed that vascular dysfunction different circulatory beds is progressively deteriorating with CKD severity. This study evaluated muscle oxygenation microvascular reactivity at rest, during an occlusion-reperfusion maneuver, exercise patients pre-dialysis versus controls, as well between stages Method Continuous meas...

BACKGROUND Adhesion of polymorphonuclear neutrophils and platelets to the vessel wall contributes to generating ischemia-reperfusion injury. Endothelial adhesion molecules are harbored within the glycocalyx, which covers every healthy vascular endothelium but is deteriorated by ischemia-reperfusion. Pretreating the heart with volatile anesthetics reduces myocardial infarct size and protects aga...

The purpose of this study is to evaluate the preventive effects Urtica dioica (UD) on muscle ischemia/reperfusion (I/R) injury. A total 27 male Wistar rats were divided into three groups as control group (1), I/R + saline (2), and I/R+UD (3). Group 1 did not receive any treatment. 2 was administered a 2mL/kg (1mL/kg before ischemia mL/kg after reperfusion), 3 given 2mL UD 1mL/kg reperfusion) Sa...

Objective Improvement in ex vivo lung perfusion protocols could increase the number of donors available for transplantation and protect lungs from primary graft dysfunction. We hypothesize that perfusate adsorption during reconditions allograft to ischemia–reperfusion injury after transplantation. Methods Donor pig were preserved 24 hours at 4°C, followed by 6 according Toronto protocol. The wa...