BACKGROUND The Unified Huntington's Disease Rating Scale (UHDRS) is the principal means of assessing motor impairment in Huntington disease but is subjective and generally limited to in-clinic assessments. OBJECTIVE To evaluate the feasibility and ability of wearable sensors to measure motor impairment in individuals with Huntington disease in the clinic and at home. METHODS Participants wi...

243. Watch Out! Syphilis Is Back – Case Series of Four Cases of Ocular syphilis Hesham Awadh, MD; Haresh Visweshwar, MD; Jacob Kilgore, MD and Kara Willenburg, MD; Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Medicine-Pediatrics, Marsha...

243. Watch Out! Syphilis Is Back – Case Series of Four Cases of Ocular syphilis Hesham Awadh, MD; Haresh Visweshwar, MD; Jacob Kilgore, MD and Kara Willenburg, MD; Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Medicine-Pediatrics, Marsha...

Huntington disease is an incurable, dominant neurodegenerative disorder caused by polyglutamine repeat expansion in the huntingtin protein. Reducing mutant huntingtin expression may offer a treatment for Huntington disease. RNA interference has emerged as a powerful method to silence dominant disease genes. As such, it is being developed as a prospective Huntington disease therapy. Here I discu...

243. Watch Out! Syphilis Is Back – Case Series of Four Cases of Ocular syphilis Hesham Awadh, MD; Haresh Visweshwar, MD; Jacob Kilgore, MD and Kara Willenburg, MD; Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Medicine-Pediatrics, Marsha...

PURPOSE To describe the clinical and radiologic manifestations of juvenile Huntington disease and to determine whether adult imaging criteria for Huntington disease are helpful for pediatric patients. METHODS Six patients (3 to 18 years of age; mean age, 9.8 +/- 5.6 years; 3 female, 3 male) with juvenile Huntington disease were studied with CT (n = 6) and/or MR (n = 3). CT and MR studies were...

Huntington disease is a neurodegenerative disorder caused by an expanded CAG repeat in the Huntington disease gene. The symptomatic phase of the disease is defined by the onset of motor symptoms. However, psychiatric disturbances, including depression, are common features of Huntington disease and recent studies indicate that depression can occur long before the manifestation of motor symptoms....

OBJECTIVES Individuals at risk for Huntington disease face difficult decisions regarding their reproductive options. Most do not wish to pass on the gene for Huntington disease to their children, but may not be prepared themselves to undergo presymptomatic testing and learn their genetic status. For these reasons, many at-risk individuals with a family history of HD would choose a method of gen...

243. Watch Out! Syphilis Is Back – Case Series of Four Cases of Ocular syphilis Hesham Awadh, MD; Haresh Visweshwar, MD; Jacob Kilgore, MD and Kara Willenburg, MD; Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Internal Medicine, Marshall University – Joan C Edwards School of Medicine, Huntington, West Virginia, Medicine-Pediatrics, Marsha...