INTRODUCTION Hearing loss is fairly a common disorder which is usually treated with corticosteroids via systemic administration and/or intra-tympanic injection. This study aimed to compare the effectiveness of intra-tympanic injections of dexamethasone with its combination with hyaluronic acid in patients with sudden sensorineural hearing loss. MATERIALS AND METHODS In this clinical trial, 40...

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.

The appearances and nature of mucin complexes have been studied intensively with synovial fluid and similar concentrations of hyaluronic acid, but there is a paucity of information about mucin complexes precipitated from very dilute hyaluronic acid (for example, 2 to 20 Ktg./ml.), which can probably be attributed to the rarity of natural solutions of this order except in bacterial and cellcultu...

Intra-articular inflammation is associated with a reduction in viscosity of synovial fluid which is due to changes in hyaluronic acid rather than in the protein component of the fluid (Kulonen, 1951; Sundblad, 1953). Hyaluronic acid is a polymer of molecular weight greater than 1 x 106 made up from repeating units of N-acetyl-D-glucosamine and D-glucuronic acid. It is present in concentrations ...

INTRODUCTION Health care professionals are constantly seeking novel approaches to treat pressure ulcers because of the impact they have on patient quality of life and health, as well as the costs associated with treating them. METHODS A review of the literature from 2002-2012 was conducted on the clinical usefulness of hyaluronic acid in tissue regeneration. Reports suggest that the therapeut...

PURPOSE Endoscopic injection of dextranomer/hyaluronic acid is an option for primary vesicoureteral reflux. Few groups have assessed the rate of urinary tract infection after dextranomer/hyaluronic acid injection. We reviewed our experience with dextranomer/hyaluronic acid injection, and determined the incidence of and risk factors for postoperative urinary tract infection. MATERIALS AND METH...

PURPOSE This study was performed to separately assess the aqueous flow applied with hyaluronic acid, and the behaviour of hyaluronic acid itself on the ocular surface. METHODS Two different fluorescent dyes, fluorescein sodium dissolved in 0.1% hyaluronic acid (HA) solution and 0.1% fluorescein conjugated with hyaluronic acid (F-HA) dissolved in saline, were used. A volume of 20 mul of tested...

Intra-articular injection of hyaluronic acid (HA) is well known to improved pain and function in patients with osteoarthritis (OA) [1,2]. As for rheumatoid arthritis (RA) patients with knee osteoarthritis, current medication for injection therapy includes steroid, hyaluronic acid, and platelet-rich plasma (PRP). In this article, we collected current studies regarding to this issue and suggest f...

Background. This study, a randomized controlled trial, aims to demonstrate a clinically significant improvement in subacute and chronic otitis media with effusion through the administration of hyaluronic acid associated with hypertonic solution compared with the administration of hypertonic solution alone. The setting was an outpatient clinic of 20 primary care pediatrician offices affiliated w...