OBJECTIVE Overgeneral autobiographical memory has become a well established phenomenon within major depressive disorder (MDD). Neuroendocrinologically, MDD is often characterized by a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, i.e. hypercortisolemia and reduced feedback sensitivity. In healthy participants cortisol administration has been found to impair autobiographical me...

skeletal muscle is a highly differentiated tissue with very specific functions which has low potential of regeneration. skeletal muscle injuries especially in athletes almost have lead to muscular dysfunctions and healing may be prolonged for several years. therefore, working on skeletal muscle differentiation remained an importance in biomedical researches. adipose derived stem cells (adscs) a...

For decades, compounding dermatologists have employed sulfur with topical hydrocortisone acetate for chronic facial conditions like rosacea and seborrheic dermatitis. The addition of precipitated sulfur prevented the development of acneiform eruptions, rebound phenomenon, and perioral dermatitis from the hydrocortisone. Even after long term use, these compounds can be discontinued without rebou...

BACKGROUND We developed a modified-release hydrocortisone, Chronocort, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption, and it is important to assess their impact when replicating a physiological rhythm. SUBJECTS AND METHODS In vitro dissolution to study impact of alcohol and pH on Chronocort. A phase 1, three-period,...

Glucocorticoids have multiple systemic effects that may influence bone metabolism but also directly affect osteoblasts by decreasing their proliferation. Using human osteoblastic SaM-1 cells, we examined whether the effects of hydrocortisone on cellular proliferation are mediated by hepatocyte growth factor (HGF). Human osteoblasts constitutively express both HGF and c-Met, its receptor. Hydroc...

Hydrocortisone addition to cell cultures of the Reuber (H-35) hepatoma initiated an 8to IO-fold increase in tyrosine transaminase (L-tyrosine:Z-oxoglutarate aminotransferase, EC 2.6.1.5) levels, the response being maximal at 9 hours and persisting at this new level for at least 36 hours. The optimal concentration of hydrocortisone for this induction was 5 X low7 M. Insulin was also found to ele...

Cushing's syndrome requires glucocorticoid replacement following adrenalectomy. Based on a simplified glucocorticoid therapy scheme and the peri-operative observation, we investigated its efficacy and safety up to 6 months post-adrenalectomy in this cohort study. We found the adrenocorticotropic hormone (ACTH) levels were normal post-adrenalectomy, and sufficient to stimulate the recovery of th...

In order to rise the yield of prednisolone from hydrocortisone, the Pseudomonas oleovorans cells were entrapped into radiation crosslinked poly (vinyl pyrrolidone)/poly(ethylene oxide) (PVP/PEO) hydrogel of different gel contents. The factors affecting the gel content and swelling behavior of the polymeric gel, such as polymer composition, polymer blend concentration, and irradiation doses, wer...

It is still not commonly realized that immediate hypersensitivity reactions to hydrocortisone can occur. A rare case is reported which illustrates the need for caution when using this drug in atopic subjects. Ideally, parenteral hydrocortisone should only be used where facilities for resuscitation are available.