tions of hydrocortisone and cortisone to man have established the plasma half-life of hydrocortisone to be 2 hours and that of cortisone 1 hour (1, 2). From isotopic determinations in urine, the half-life of hydrocortisone in the body has been found to be 6 hours and that of cortisone 3.6 hours (3, 4). Thus, cortisone is not only cleared from the plasma more rapidly than hydrocortisone but it i...

Background/Objective. Hydrocortisone, administered to ventilated preterm neonates to facilitate extubation, has no adverse long-term effects, but short-term pulmonary effects have not been described previously. In the present study, we analyzed effects of hydrocortisone on ventilator settings and FiO(2) in ventilator-dependent preterm infants. Patients and Methods. Fifty-five preterm children w...

BACKGROUND AND OBJECTIVES Post-dural puncture headache is the most frequent complication after spinal anesthesia or accidental dural perforation during attempted epidural block. This report aimed at describing the use of hydrocortisone to treat and prevent post-dural puncture headache (PDPH). CASE REPORTS Three cases in which hydrocortisone was used to treat and prevent post-dural puncture he...

introduction: shorter hospital stay and less pain in comparison to open surgery considered to be major benefits for laparoscopic cholecystectomy. we compared the effect of intraperitoneal hydrocortisone plus bupivacaine with bupivacaine alone on pain relief following laparoscopic cholecystectomy.  methods: sixty two patients participated in this double-blind, randomized clinical trial. patients...

OBJECTIVE There is much concern about potential neurodevelopmental impairment after neonatal corticosteroid treatment for chronic lung disease. Dexamethasone is the corticosteroid most often used in this clinical setting, and it has been shown to impair cortical growth among preterm infants. This study evaluated long-term effects of prematurity itself and of neonatal hydrocortisone treatment on...

-The role of adsorbed and structural Fe n+ in palygorskite and sepiolite with respect to the oxidation of hydrocortisone in aqueous suspension has been evaluated using electron spin resonance and UVvisible spectroscopy. Natural surface-adsorbed Fe 3+ showed an important activity in the oxidation process, although smaller than octahedral Fe 3+. The kinetics of oxidative degradation of hydrocorti...

Experimental interference with the circulation in a circumscribed tissue area, too slight to produce any manifest disturbance in itself, can strikingly alter topical reactivity to irritants and to the antiphlogistic effect of hydrocortisone. Thus, certain vascular territories can be "selectively conditioned" to the anti-inflammatory actions of blood-borne corticoids. Conversely, when tissue dam...

BACKGROUND Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. OBJECTIVES To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants. METHODS Randomised controlled trials (RCTs) of postnatal hydrocortisone ther...

INTRODUCTION Patients who need glucocorticoid replacement in both primary and secondary adrenal insufficiency (AI) have the choice of either once-daily prednisolone or thrice-daily hydrocortisone. A recent European study found no difference between prednisolone and hydrocortisone users in several markers including glucose, weight, body mass index, systolic and diastolic blood pressure and waist...

AIM To compare the efficacy of hydrocortisone with dopamine for the treatment of hypotensive, very low birthweight (VLBW) infants. METHODS Forty infants were randomly allocated to receive either hydrocortisone (n = 21) or dopamine (n = 19). RESULTS All 19 infants randomised to dopamine responded; 17 of 21 (81%) did so in the hydrocortisone group. Three of the four non-responders in the hydr...