The objective of the present study was to develop sustained release oral matrix tablets of anti epileptic drug levetiracetam. The sustained release matrix tablets of levetiracetam were prepared using hydrophilic matrix hydroxypropyl methylcellulose (HPMC) as a release retarding polymer by wet granulation method. Prior to compression, FTIR studies were performed to understand the compatibility b...

Polyethersulfone (PES) based nanocomposite nanofiltration membrane was prepared by immersion precipitation method and casting solution technique using  poly (acrylic acid) grafted-iron oxide nanoparticles (Fe3O4) as hydrophilic filler additives. For this purpose, iron oxide nanoparticles were modified by in situ polymerization of acrylic acid in aqueous solution by potassium persulfate as initi...

In this study, a polymer-silica nanocomposite using the sol-gel method was synthesized in three steps at room temperature. The nanocomposite material was formed with an organic compound (polyethylene glycol) and inorganic silica nanoparticles. Furthermore, the size and the distribution of nanoparticles in the polymer matrix were characterized by a transmission electron microscope (TEM).  In add...

In this study, novel polycarbonate-titanium oxide nanotubes (PC-TNT) ultrafiltration mixed matrix membranes (MMMs) were fabricated for decontamination of Cd2+ and Cu2+ metal ions from aqueous solution. The weight percent of TNTs in the polycarbonate membrane matrix was changed from 0 to 15. The synthesized neat PC membrane and PC-TNTs MMMs were characterized with respect to structural morpholog...

purpose : to report clinical and pathological features of three cases of opacification with hydrophilic acrylic intraocular lenses (iols) case reports : in this interventional case report, we introduce the surgical and laboratory information about three hydrophilic acrylic iols which calcified after implantation for these patients with cataract. these lenses were explanted and analyzed with opt...

a hydrophilic macromolecular network is prepared by performing graft copolymerization of poly (sodium acrylate) chains onto salep and silica gel. the reaction parameters affecting the water absorbency of the superabsorbent composite were optimized using taguchi method. ft-ir spectroscopy and thermo gravimetric analysis (tga) were used for confirming the structure of the final product and morpho...

In this study,formulation of sustained-releasingmatrix tablet of bupropion 150 mg, using hydroxypropylmethylcellu lose(HPMC) 4000cps was evaluatedwith the aim of reducing the frequency of daily dose. The level of HPMC4000 ,polyvinylpyrolidone(PVP) and magnesium stearate(Mg St)was varied based on a 2level 3 factor factorial experimental designusing the release rate of the drug from the matrices ...

Specific : buoyancy, clinical study, cut-off size, dimension monitoring, dosage form size, floating dosage form, floating force, gamma scintigraphy triple radiolabeling and monitoring technique, gastric emptying, gastric residence time, Hydrodynamically Balanced System (HBS), intragastric buoyancy, monolithic hydrophilic matrix, non-floating dosage form, resultant-weight measuring apparatus and...

Molecularly imprinted polymers bearing peptide fragment-based binding sites within the protein-imprinted cavities were prepared by copolymerization of the acrylated protein with 6-monoacryloyl-trehalose and 6,6'-diacryloyl-trehalose as a hydrophilic comonomer and a crosslinker respectively, followed by enzymatic decomposition of the grafted protein into the polymer matrix with pepsin, resulting...