Background: Melasma is an acquired therapeutically problematicdisease characterized by symmetrical facial hypermelanosis. Theaim of this study was to evaluate the efficacy of azelaic acid20% cream in the treatment of melasma in Iranian patients andcompare it with hydroquinone 4% cream which has been thestandard treatment.Method: The study was an open clinical trial with a split-facedesign. All ...

Pentachlorophenol (PCP) is a toxic pollutant. Its biodegradation has been extensively studied in Sphingobium chlorophenolicum ATCC 39723. All enzymes required to convert PCP to a common metabolic intermediate before entering the tricarboxylic acid cycle have been characterized. One of the enzymes is tetrachloro-p-hydroquinone (TeCH) reductive dehalogenase (PcpC), which is a glutathione (GSH) S-...

the method has been developed and validated for the determination of hydroquinone in liposomal formulation. the samples were dissolved in methanol and evaluated in 293 nm. the validation parameters such as linearity, accuracy, precision, specificity, limit of detection (lod) and limit of quantitation (loq) were determined. the calibration curve was linear in 1-50 µg /ml range of hydroquinone an...

Objective: To compare the efficacy and safety of topical silymarin 0.7% with hydroquinone 4% in treatment melasma.
 Place Duration: This Randomized Controlled Trial was conducted at dermatology OPD Akbar Niazi Teaching Hospital, Bara Kahu, Islamabad, a period one year from April 2020 to 2021.
 Patients Methods: Female patients having melasma were included study. The severity assessed ...

Bone marrow is a major target of benzene toxicity, and NAD-(P)H:quinone oxidoreductase (NQO1), an enzyme protective against benzene toxicity, is present in human bone marrow endothelial cells, which form the hematopoietic stem cell vascular niche. In this study, we have employed a transformed human bone marrow endothelial cell (TrHBMEC) line to study the adverse effects induced by the benzene m...

cell cultures of varthemia persica, peganum harmala and pycnocycla spinosa have been studied to evaluate their abilities to bioconvert exogenous hydroquinone. arbutin is an important substance that has several pharmaceutical applications; therefore, we have established v. persica and p. spinosa cultures which seem to be able to metabolize hydroquinone. callus cultures of v. persica were establi...

Hydroquinone was found to suppress bubble formation at the outlet electrode of a sheathless capillary electrophoresis/electrospray ionization-mass spectrometer by replacing the oxidation of water (2H2O(1)<-->O2(g) + 4H+ + 4e) with that of more easily oxidized hydroquinone (hydroquinone<-->p-benzoquinone + 2H+ + 2e). Formation of p-benzoquinone replaces the formation of oxygen gas, effectively s...

In this microcosm study, we analyzed the effect produced by hydroquinone on the expression of soil biological denitrification, in relation to the redox state of the soil, both in terms of intensity factor (Eh') and capacity factor (amount of oxidized or reduced compounds). The supplementation of an Argiudoll soil with hydroquinone decreased the soil apparent reduction potential (Eh') and soil d...

Background and aims: Melasma is an acquired hyperpigmentation on the face, which generally happens in women between the ages of 30 to 35. If treatment is not performed in a timely manner, many cosmetic problems can arise. The aim of this study was to compare the effects of kojic acid and hydroquinone 2% creams for the treatment of melasma. Methods: 100 women with epidermic melasma who were refe...

The phenolic glycoside arbutin and its metabolite with uroantiseptic activity hydroquinone occur naturally in the leaves of various medicinal plants and spices. In this study, an extraction procedure coupled with gas chromatography-mass spectrometry (GC-MS) was developed to determine arbutin and hydroquinone content in strawberry tree (Arbutus unedo L., Ericaceae) leaves. The method showed good...