An attempt was made to study the bioactive compounds from a terrestrial Streptomyces sp. ANU 6277 isolated from laterite soil. Four active fractions were recovered from the solvent extracts obtained from the culture broth of five day-old strain. Three bioactive compounds were purified and identified as 3-phenylpropionic acid, anthracene-9,10-quinone and 8-hydroxyquinoline. The components of the...

Quinoline, which belongs to N-heterocyclic compounds, occurs naturally in the environment and is used in numerous industrial processes. The structures of various chemicals, such as dyes and medicines, are based on this compound. Due to that fact, quinoline and its derivatives are widely distributed in environment and can exert toxic effects on organisms from different trophic levels. The abilit...

2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ) with that of two other commonly used 2OG oxygenase inhibitors, N-oxalylglycine (NOG) and 2,4-pyridinedicarboxylic acid (2,4-PDCA). The results reve...

background: clomiphene citrate (cc) an agonist and antagonist of estrogen, is the first line treatment in ovarian stimulation. anti-estrogenic effect of cc in endometrial thickness and cervical mucus has negative effect on pregnancy rate. letrozole is an aromatase inhibitor has been seen that has acceptable pregnancy rate compared to cc. objective: the aim of this study was to compare the effic...

in the present work, magnetic nanocomposites of the multi-walled carbon nanotubes (mwcnts) decorated with magnesium ferrite (mgfe2o4) nanoparticles were synthesized successfully by citrate-gel method. the shape, structure, size, and properties of the as-synthesized sample were characterized by fourier transform infrared spectroscopy (ftir), x-ray diffraction pattern (xrd), transmission electron...

this study was designed to compare the effect of clomiphene and letrozole in ovulatory stimulation in infertile women under intrauterine insemination who referred to mahdiyeh infertility clinic during 2008-2009. 106 infertile women were randomly divided into two equal groups. patients were treated with 5 mg of letrozole daily (in letrozole group) or 100 mg of clomiphene citrate daily (in clomip...

The spectroscopy, electrochemistry, and electrogenerated chemiluminescence (ECL) of [(q)(qH)Li]x (qH=8-hydroxyquinolinato) and [(Meq)(MeqH)Li]x (MeQH=2-methyl-8-hydroxyquinolinato) have been investigated. In both acetonitrile and aqueous solutions, [(q)(qH)Li]x and [(Meq)(MeqH)Li]x have absorption maxima at 320 and 309 nm, respectively. When excited at these wavelengths, the complexes emit arou...

Structures containing 8-hydroxyquinoline scaffold are useful for anticancer drug development. The title ester (5-chloroquinolin-8-yl)-2-fluorobenzoate was prepared by the reaction of 2-fluorobenzoyl chloride with 5-chloro-8-hydroxyquinoline. The structure of the title compound was assigned by diverse spectroscopic techniques. Moreover, a crystallographic study was undertaken and its supramolecu...