BACKGROUND AND PURPOSE Hyperglycemia is linked to a worse outcome after ischemic stroke. Among the manifestations of brain damage caused by ischemia are blood-brain barrier (BBB) disruption and edema formation. Oxidative stress and matrix metalloproteinase-9 (MMP-9) activation are implicated in BBB dysfunction after ischemia/reperfusion injury. Our present study was designed to clarify the rela...

BACKGROUND Since hyperglycemia-induced cellular dysfunction could be associated with alterations of the immune system, we tested the hypothesis that hyperglycemia augments the aberrant immune responses such as inflammation and differentiation of CD4(+) T lymphocytes in the mesenteric lymph nodes (MLNs), and induces alterations of microbiota both under physiological and pathological conditions. ...

context turmeric is obtained from the plant curcuma longa l; its major constituent, curcumin, is a polyphenol with multiple effects which can modulate some signaling pathways. evidence acquisition insulin resistance is a major risk factor for chronic diseases such as type 2 diabetes, atherosclerotic, metabolic syndrome and cardiovascular disease. in addition, insulin resistance in peripheral ti...

objective(s):hyperglycemia worsens the neuronal death induced by cerebral ischemia. previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (hsp70 and 60) in the liver. igg antibody titres against heat shock protein 27 (anti hsp27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the exp...

background: the growing number of people with diabetes mellitus and its complications shows the need to focus on ways to control diabetes mellitus through improving lifestyle, dietary patterns and physical activity. this systematic review assesses the effects of healthy dietary patterns on managing hyperglycemia, insulin resistance and diabetes mellitus type 2. methods: the main keywords used i...

anxiety symptoms have been reported to be present in many patients with diabetes mellitus. however, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. we assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. our findin...

BACKGROUND Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with myocardial infarction and stroke, especially in patients with diabetes. The induction of PAI-1 expression by hyperglycemia involves oxidative stress and protein kinase C (PKC). However, the mechanism by which hyperglycemia increases PAI-1 expression is unknown. METHODS AND RESULTS Compared with normogl...

Adipokines have many homeostatic roles, including modulation of glucose metabolism, but their role in the pathophysiology of hyperglycemia associated with acute and critical illnesses in general, and acute pancreatitis (AP) in particular, is largely unknown. This study aimed to investigate the relationship between a panel of adipokines and hyperglycemia in the early course of AP, as well as the...

Hyperglycemia upon hospital admission in patients with ST-segment elevation myocardial infarction (STEMI) occurs frequently and is associated with adverse outcomes. It is, however, unsettled as to whether an elevated blood glucose level is the cause or consequence of increased myocardial damage. In addition, whether the cardioprotective effect of exenatide, a glucose-lowering drug, is dependent...

A rodent model of controlled acute hyperglycemia that is sensitive to glucose-lowering agents insulin and glucagon-like peptide-1 (GLP-1) analog has been developed. The studies show that anesthesia could be induced in fasted rats with ketamine (100 mg/kg) plus a low dose of xylazine (5 mg/kg) without inducing the acute hyperglycemia typically associated with these agents. Under these conditions...