Background: Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. Due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153Sm]-samarium maltolate was developed for possible therapeutic applications. Materials and Methods: The or...

The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be particularly sensitive to PAE-induced zinc depletion. PAE-induced changes in male ...

Background & Aim:Hypericum perforatum L. is native to Iran. This herb is one of the most important medicinal plants and had many medical effects.This experiment was conducted to investigate the effects of feeding Hypericum perforatum and protexin on performance, carcass characteristics and intestinal morphology Japanese quails. Experimental: ...

Cadherins, being responsible for selective cell recognition and normal tissue integrity in adults, regulate morphogenesis in a variety of organs during development. In this study, anti-rat pan-cadherin antibody, specific to all subgroups of the cadherin family, was used to map the distribution of the pan-cadherin immunoreactivity in adult rat organs. Pan-cadherin immunoreactivity positive tissu...

105 Keyword Index 106 Introduction 106 Results/Discussion 108 Conclusions and Concluding Remarks 117 Experimental 117 Acknowledgements 122 Literature Cited 123 Tables 127 Figure Legends 131 Figures 133 CHAPTER 5. IDENTIFICATION OF PATHWAYS IMPORTANT FOR THE ANTI-INFLAMMATORY ACTIVITY OF AN HYPERICUM PERFORATUM FRACTION AND FOUR PUTATIVE BIOACTIVE CONSTITUENTS IN RAW 264.7 MOUSE MACROPHAGES USIN...

The phloroglucinol derivative hyperforin has been recently shown to be a major antidepressant component in the extract of Hypericum perforatum. Experimental studies clearly demonstrated its activity in different behavioral models of depression. Moreover clinical studies linked the therapeutic efficacy of Hypericum extracts to their hyperforin content, in a dose-dependent manner. The molecular m...

Background & Aim:Hypericum perforatum L. is native to Iran. This herb is one of the most important medicinal plants and had many medical effects.This experiment was conducted to investigate the effects of feeding Hypericum perforatum and protexin on performance, carcass characteristics and intestinal morphology Japanese quails. Experimental: ...

We present a systematic review of observational studies of hypericum extracts in the treatment of depressive disorders. We included non-randomized studies with at least 100 patients suffering from depressive disorders treated with hypericum mono-preparations for at least 4 weeks, which reported clinical outcomes. Potentially relevant studies were identified through searches in electronic databa...