Objective: Hypericum perforatum has demonstrated antidepressant efficacy when compared to placebo, but comparisons with other antidepressants remain controversial. We assessed the efficacy and safety of Hypericum perforatum in comparison with fluoxetine, in a 8-week double-blind trial in patients with mild to moderate depression. Method: Seventy-two outpatients were randomly assigned to receive...

The aim of this study was investigate antihyperglycemic effect of ethyl acetate extracts of leaves and stem of Hypericum hookerianum (HH) as in streptozotocin and nicotinamide induced diabetic rats. Male Wistar rats were administrated with leaf (HHL) and stem(HHS) extracts (200 mg/kg)of Hypericum hookerianum orally for 28days and blood glucose was measured once in week about 4weeks.The HHL extr...

Hypericum species, growing wild in Anatolia, widely used in traditional medicine in Turkey. In order to determine the genotoxic effect of Hypericum heterophyllum, human lymphocytes were incubated with the aqueous extracts. The increasing extract concentrations of Hypericum heterophyllum induced micronucleus. The rise of micronucleus shows that Hypericum heterophyllum at high concentrations may ...

Since ancient times, the essential oils (EOs) of many aromatic plants have been used as bioactive ingredients in drug, food and cosmetic formulations all over the world. Significant biological properties have also been attributed to Hypericum EOs. Hypericum is a genus of about 450 species in the Guttiferae family, formerly often treated separately in their own Hypericaceae family. Despite the l...

Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs. This study examined the influence of acute pretreatment with different extracts of Hypericum perforatum from Serbia on pentobarbital-induced sleeping time, impairment of mot...

Abstract Three new compounds ( 1 – 3 ) with unusual skeletons were isolated from the n -hexane extract of air-dried aerial parts Hypericum scabrum . Compound represents first example an esterified polycyclic polyprenylated acylphloroglucinol that features a unique tricyclo-[4.3.1.1 1,4 ]-undecane skeleton. 2 is fairly simple MPAP, but unexpected cycloheptane ring decorated prenyl substituents, ...

OBJECTIVE To investigate the efficacy of hypericum extract WS 5570 (St John's wort) compared with paroxetine in patients with moderate to severe major depression. DESIGN Randomised double blind, double dummy, reference controlled, multicentre non-inferiority trial. SETTING 21 psychiatric primary care practices in Germany. PARTICIPANTS 251 adult outpatients with acute major depression with...

St John's wort (Hypericum perforatum) is a traditional herbal medicine that is used for the topical treatment of superficial wounds, burns and dermatitis. The characteristic metabolites of St John's wort are the photodynamic active plant pigment hypericin and the phloroglucin-derivative hyperforin. To date, no studies on immunomodulatory properties of topical preparations of St John's wort have...

OBJECTIVES To assess the efficacy and safety of hypericum extract (STEI 300, Steiner Arzneimittel, Berlin) compared with imipramine and placebo in patients in primary care with a current episode of moderate depression. DESIGN Randomised, double blind, multicentre, parallel group trial for 8 weeks. SETTING Trained panel of 18 general practitioners from four German states: Bavaria, Berlin, Rh...