1. Abstract 2. Introduction 3. Hypersensitivity reactions 3.1. Hypersensitivity to nevirapine and other NNRTIs 3.2. Hypersensitivity to abacavir 3.3. Hypersensitivity to other antiretrovirals 3.4. Treatment of hypersensitivity reactions 4. Hyperlactatemia-steatosis syndrome 5. Liver toxicity 6. Pancreatitis 7. Gastrointestinal intolerance 8. Nervous system toxicity 8.1. Central nervous system s...

Canine babesiosis typically causes hemolytic anemia but also can result in multiple organ dysfunction. Human patients with severe disease often have persistent hyperlactatemia, and blood lactate concentration is correlated with survival rate. In dogs, blood lactate concentration has been shown to be of prognostic value in patients with gastric dilatation-volvulus and in dogs admitted to intensi...

Children with cystic fibrosis are commonly colonized with multi-resistant bacteria. In such patients, infectious exacerbation may require salvage therapy with uncommonly used antimicrobials, including chloramphenicol. Chloramphenicol is rarely used nowadays because of the associated severe adverse events. We describe the case of a 15-year-old female with terminal cystic fibrosis who required in...

BACKGROUND Recent clinical studies have confirmed the strong prognostic value of persistent hyperlactatemia and delayed lactate clearance in septic shock. Several potential hypoxic and nonhypoxic mechanisms have been associated with persistent hyperlactatemia, but the relative contribution of these factors has not been specifically addressed in comprehensive clinical physiological studies. Our ...