To clarify the clinical implication of preheparin serum lipoprotein lipase mass (preheparin LpL mass), we studied the relationships between preheparin LpL mass and serum lipids, including midband lipoproteins, which migrate between very low density lipoproteins and low density lipoproteins on polyacrylamide gel disc electrophoresis, in hyperlipidemias. And we also studied the changes of prehepa...

OBJECTIVES The possible link between folic acid or folate and tetrahydrobiopterin (H(4)B), vitamin C, polyunsaturated fatty acids (PUFAs), and nitric oxide (NO), which may explain the beneficial actions of these nutrients in various vascular conditions, was investigated. METHODS The literature pertaining to the actions of folic acid/folate, H(4)B, vitamin C, PUFAs, and NO was reviewed. RESU...

Bariatric surgery developed in the late 1970 to treat severe hyperlipidemias in overweight individuals, not necessarily obese. Several techniques have been developed, and the concept has come first of a surgery for morbid obesity, then of a cure for diabetes in morbid obesity. There are other aspects of bariatric surgery that deserve attention, beyond BMI and diabetes, such as hypertension, poo...

Background. Different patterns of risk factors might be related to the involvement of specific vascular districts by atherosclerosis. In this sense, many investigations have addressed coronary artery disease, whereas extracoronary atherosclerosis has received less extensive attention. Methods and Results. Vascular risk factors, with particular attention to lipid parameters (total cholesterol [T...

Platelets were obtained from patients with various hyperlipidemias [type II, type V, lecithin-cholesterol acyltransferase (LCAT) deficiency] and hypolipidemias (abetalipoproteinemia, Tangier disease) to ascertain relationships among plasma lipids, platelet lipids, thrombin binding and thrombin-induced platelet aggregation, and to compare these data with those previously obtained on stimulus-res...

BACKGROUND Different patterns of risk factors might be related to the involvement of specific vascular districts by atherosclerosis. In this sense, many investigations have addressed coronary artery disease, whereas extracoronary atherosclerosis has received less extensive attention. METHODS AND RESULTS Vascular risk factors, with particular attention to lipid parameters (total cholesterol [T...

Phvsiological Chemistry of Lipids in Mamumals by Edward J. Masoro is the first of a series of short monographs designed "not only to introduce the student to the fundamentals of biochemistry but also to show how these biochemical principles apply to various areas of mammalian physiology and pathology." The goal is not attained. The first 179 pages present the chemistry of fatty acids, steroids,...

To the Editor: The comprehensive review by Furberg1 of natural statins and stroke raises a number of issues. Stroke was a secondary end point in these studies in patients with cardiovascular disease (CVD). Primary end-point trials in stroke are awaited. Surrogate markers can be valuable guides to the introduction of better therapies before large-scale trials are completed. LDL may be the best s...

Rywlin, Arkadi M., Lopez-Gomez, Alfredo, Tachmes, Pablo, and Pardo, Victoriano: Ceroid histiocytosis of the spleen in hyperlipemia: Relationship to the syndrome of the sea-blue histiocyte. Amer. J. Clin. Path. 56: 572-579, 1971. Morphologic findings in a patient with primary, type 5 hyperlipoproteinemia of Fredrickson and Lees, reported for the first time, include marked splenomegaly with exten...

Phvsiological Chemistry of Lipids in Mamumals by Edward J. Masoro is the first of a series of short monographs designed "not only to introduce the student to the fundamentals of biochemistry but also to show how these biochemical principles apply to various areas of mammalian physiology and pathology." The goal is not attained. The first 179 pages present the chemistry of fatty acids, steroids,...