In this issue, we salute three more outstanding scientists, Robert F. Furchgott, PhD, Louis J. Ignarro, PhD, and Ferid Murad, PhD, who have been recognized in earlier years by the Council for High Blood Pressure Research and then, in 1998, were jointly awarded the Nobel Prize in Medicine for their important contributions. In 1988, Dr Furchgott, who is the Distinguished Professor of Pharmacology...

Vaso-occlusive disease resulting from atherosclerosis and thrombosis is the leading cause of death and morbidity in the United States and other industrialized nations. Although the precise cause of atherosclerosis is unclear, an emerging paradigm suggests that atherosclerosis involves multiple pathways in which lipoprotein entry and retention, injury to the vessel wall from diverse stimuli, and...

In reviewing the trends and influences of life-style in this country on health and disease in the latter half of 20th century, we focused our attention on 4 major habits of smoking, drinking, exercise and diets, and collected data on the Japanese to conduct a meta-analysis of their relationship with serum lipids and lipoproteins, which are the metabolic risk factors most closely related to athe...

Intestinal cells synthesize and secrete chylomicrons in the postprandial state. Synthesis of these particles is defective in abetalipoproteinemia and chylomicron retention disease. Chylomicrons are very large, heterogeneous, lipid-rich particles ranging in diameters from 75 to 450 nm and function to transport dietary fat and fat-soluble vitamins to blood. The size heterogeneity of the secreted ...

The role of NAD metabolism in health and disease is of increased interest as the use of niacin (nicotinic acid) has emerged as a major therapy for treatment of hyperlipidemias and with the recognition that nicotinamide can protect tissues and NAD metabolism in a variety of disease states, including ischemia/reperfusion. In addition, a growing body of evidence supports the view that NAD metaboli...

1RaNA Therapeutics, Cambridge, Massachusetts, USA Correspondence: Arthur M Krieg, RaNA Therapeutics, 25 First Street, Suite 303, Cambridge, Massachusetts 02141, USA. E-mail: [email protected] Cardiovascular disease is the number one cause of death in the industrialized world. Much of the morbidity and mortality from heart disease can be linked to elevated low-density lipoprotein (LDL) cholester...

Insulin secretion and -cell biology are the focus of the Servier-IGIS Symposia that have been held yearly since 2000 in St. Jean Cap Ferrat in southern France (1). This volume, the fourth of a series published in Diabetes (1–3), collects the proceedings of the fourth Servier-IGIS Symposium, which focused on novel factors involved in islet biology and -cell function. Special emphasis was placed ...

Enormous personal satisfaction is frequently derived from experiences resulting from systematic clinical investigation. Such are the lessons that have been learned from the tremendous insight that has evolved concerning the careful clinical and fundamental study of new therapeutic agents, events after their release for general clinical use. This has been the case derived from exciting gains int...

Although cognitive dysfunction is considered one of the more debilitating symptoms of schizophrenia, there is a fundamental gap in our knowledge of how the primary pharmacologic treatments of this disease, firstand second-generation antipsychotics (FGAs and SGAs, respectively), affect cognition, particularly over extended periods of time. Moreover, it has been known for decades that chronic tre...