Quantifying the relationship between changes in lipid variables and clinical endpoints has been difficult. We studied the predictive value of various lipid variables on three endpoints in the Program on the Surgical Control of the Hyperlipidemias (POSCH): overall mortality, coronary heart disease (CHD) mortality, and CHD mortality and confirmed nonfatal myocardial infarction (MI) combined. We m...

Dyslipidemia is an abnormal amount of lipids (abnormality in any of the lipoprotein fractions), especially elevated Low Density Lipoprotein (LDLs) and decreased High Density Lipoprotein (HDLs) in the blood (Shalileh et al., 2009). In developed countries, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, are often due to diet and lifestyle (Wikipedia., 2011; S...

The 12th annual scientific meeting of the European Vascular Biology Association was held in Gilleleje, Denmark, from April 27 to May 1, 1991, in collaboration with the Scandinavian Society for Atherosclerosis Research. The sessions of the meeting covered two major fields: hyperlipidemias relating to the genetic variability of apolipoprotein B-100 and transendothelial flow of macromolecules. The...

BACKGROUND Recent studies have suggested that several hemostatic factors, leukocyte count, and plasma viscosity are predictive of coronary heart disease. Detailed analyses on lifestyle correlates, in particular plasma lipids and lipoproteins, of determinants of blood rheology have not been reported from epidemiological studies. METHODS AND RESULTS We studied the relation between determinants ...

The influence of hyperlipidemic sera on prostacyclin (PGI2) production by cultured endothelial cells was assessed by comparing sera from three types of hyperlipidemias with sera from normal subjects. Sera prepared from normal whole blood (WBS), platelet-rich plasma (PRPS), and platelet-poor plasma (PPPS) were also compared. Bovine aortic endothelial cells (BAEC) incubated with 25% WBS increased...

The 12th annual scientific meeting of the European Vascular Biology Association was held in Gilleleje, Denmark, from April 27 to May 1, 1991, in collaboration with the Scandinavian Society for Atherosclerosis Research. The sessions of the meeting covered two major fields: hyperlipidemias relating to the genetic variability of apolipoprotein B-100 and transendothelial flow of macromolecules. The...

OBJECTIVE Rodents are poor model for human hyperlipidemias because total cholesterol and low density lipoprotein levels are very low on a normal diet. Lipoprotein metabolism is primarily regulated by hepatocytes and we therefore assessed whether chimeric mice extensively repopulated with human cells can model human lipid and bile acid metabolism. DESIGN FRG [ F ah(-/-) R ag2(-/-)Il2r g (-/-)]...

BACKGROUND Homogeneous LDL-cholesterol methods from Genzyme, Reference Diagnostics, Roche, and Sigma were evaluated for precision, accuracy, and specificity for LDL in the presence of abnormal lipoproteins. METHODS Each homogeneous method was performed by a Roche/Hitachi 911 according to the vendors' instructions, and the results were compared with the beta-quantification reference method. We...

CONTEXT Three recent nested case-control studies conducted in automated databases suggest that users of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have a risk of hip and other osteoporotic fractures half that of non-users of any lipid-lowering drug. However, this comparison may be biased by unmeasured factors associated with treated hyperlipidemias. OBJECTIVE To comp...

ATP-citrate lyase (Acly) is one of two cytosolic enzymes that synthesize acetyl-coenzyme A (CoA). Because acetyl-CoA is an essential building block for cholesterol and triglycerides, Acly has been considered a therapeutic target for hyperlipidemias and obesity. To define the phenotype of Acly-deficient mice, we created Acly knockout mice in which a beta-galactosidase marker is expressed from Ac...