Dentin hypersensitivity is a very common clinical symptom, which consists of sharp pain arising from exposed dentin in response to various types of stimuli and thus can cause considerable concern for patients. This condition is frequently encountered by periodontists, dentists and hygienists. The management of this condition requires good understanding of the complexity of the problem, as well ...

Glucocorticoids (GCs) are master regulators of systemic metabolism. Intriguingly, Cushing's syndrome, a disorder of excessive GCs, phenocopies several menopause-induced metabolic pathologies. Here, we show that the glucocorticoid receptor (GR) drives steatosis in hypogonadal female mice because hepatocyte-specific GR knockout mice are refractory to developing ovariectomy-induced steatosis. Intr...

Two homologous lightly coupled dinitrophenyl conjugates of poly-L-lysine of differing average molecular sizes were compared with regard to their abilities to elicit in guinea pigs specific delayed hypersensitivity skin reactions, passive cutaneous anaphylaxis, and active Arthus reactions. Equal concentrations by weight (but not equimolar concentrations) of the two conjugates elicited equally in...

OBJECTIVE Adverse event reports (AERs) submitted to the US Food and Drug Administration (FDA) were reviewed to confirm the platinum agent-associated mild, severe, and lethal hypersensitivity reactions. METHODS Authorized pharmacovigilance tools were used for quantitative signal detection, including the proportional reporting ratio, the reporting odds ratio, the information component given by ...

The immune response activatesB cells to produce antibody and T cells to mediate cytotoxicity or produce cytokines. An important division in the development of T cells is their tendency to develop into subpopulations producing either TH1 or TH2 cytokines. The TH1 cytokines include interferon g, tumour necrosis factor b (TNFb) and interleukin 2 (IL-2), while the cytokines which best characterize ...

Guinea pigs infected by intradermal injection of living toxigenic diphtheria bacilli and protected by horse antitoxic globulin, given either before or after infection, develop delayed hypersensitivity of the tuberculin type to diphtherial proteins. The highest degree of hypersensitivity is specifically directed against diphtheria toxin (or toxoid) itself, although smaller delayed skin reactions...

Background Aspirin (ASA) hypersensitivity has a complex clinical presentation with three major phenotypes: aspirinexacerbated respiratory disease (AERD; asthma and/or nasal polyps), chronic urticaria and aspirin-induced anaphylaxis. In patients with AERD asthma is often severe and difficult to control. Moreover, NSAID ingestion may provoke life-threatening attack. Thus, diagnosing of ASA hypers...

Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer-related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who e...

Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to 'cough hypersensitivity syndrome' suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system,...

in agriculture, an application that accounts for approximately 40% of the total production of these agents. It is obviously impossible to give detailed descriptions of the many excellent papers in this volume, but some points may be noted. From a pharmacological viewpoint, the area of structure-activity relationships is particularly well covered in regard to penicillins (K. et al.) and lincomyc...