Because humans lack uricase, they cannot convert the uric acid generated during purine metabolism into a soluble form. This can lead to an increased risk for hyperuricemia and monosodium uric acid crys-tallization in joints and tissues, a hallmark of gout. Hyperuricemia can be caused by the overproduction of uric acid, but is more often the result of insufficient kidney uric acid excretion. Bec...

Hyperuricemia is associated with cardiovascular risk. The present study examines the association between serum uric acid (UA) elevation and the alpha2-, beta2-, and beta3-adrenoceptor polymorphisms. In 219 nonobese, normotensive, normouricemic (serum UA <6.5 mg/dL at entry) men, serum UA, plasma norepinephrine (NE), the homeostasis model assessment of insulin resistance (HOMA-IR), body mass ind...

Ganoderma applanatum (G. applanatum) dispels wind to eliminate dampness and exhibited nephron- and liver-protective effects as noted in Chinese herbal classic literature; it might also affect hyperuricemia. Therefore, we examined the hypouricemia effects and mechanisms underlying G. applanatum on chemical-induced hyperuricemia in mice. Ethanol (GAE) and water (GAW) extracts were prepared by ext...

BACKGROUND Studies have associated betel nut chewing with cancers, metabolic syndrome, cardiovascular disorders, chronic kidney disease, and proteinuria. This study investigated whether hyperuricemia is associated with betel nut chewing in men who participated in a health check-up program. METHODS From hospital records, we identified a total of 11,991 men who participated in the health check-...

Background: Atypical antipsychotics have been found to be associated with hyperuricemia. Risperidone, one of the atypical antipsychotics, might be related to the hyperuricemia among autism spectrum disorder (ASD) patients. The aims of this study were to determine the prevalence of hyperuricemia in ASD patients treated with risperidone and to determine associations between serum uric acid levels...

BACKGROUND Mounting evidence indicated that the elevated serum uric acid level was associated with an increased risk of acute kidney injury (AKI). Our goal was to systematically evaluate the correlation of serum uric acid (SUA) level and incidence of AKI by longitudinal cohort studies. METHODS We searched electronic databases and the reference lists of relevant articles. 18 cohort studies wit...

The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. authors performed this cross-sectional study to determine the MS among diabetic patients Dakar. Type 2 received as part of their follow-up at Marc Sankal&eacute; Center Abass Ndao Hospital Dakar were enrolled. For each patient, blood samples 24 h urine collection performed. Hyperuricemia was def...