42 Background: This is a rare instance of acute kidney injury caused by hyperuricemia due to 43 spontaneous tumor lysis syndrome and also the first case of spontaneous tumor lysis syndrome 44 reported in association with myelodysplastic syndrome. Case Presentation: A 53-year-old man 45 presented with abrupt oliguria. Laboratory findings on admission included hyperuricemia, 46 hyperphosphatemia,...

Recent studies have focused on hyperuricemia as a modulator for metabolic syndrome. Hyperuricemia has reported in many studies as a causal marker in a higher prevalence of metabolic syndrome. In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. High level of uric acid has been associated ...

BACKGROUND Metabolic syndrome is a cluster of the most dangerous heart attack risk factors such as diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. Hyperuricemia is a condition in which the serum uric acid concentration is greater than 5.5 mg per deciliter for child and greater than 7.2 and 6.0 mg per deciliters for male and female adults respectively. ME...

Chronic kidney disease (CKD) is a structural and function disorder of renal for > 3 months with implications individual health. CKD has become health problem throughout the world its implementation provides considerable economic burden on system. The decreasing value GFR (glomerular filtration rate) in can cause uric acid retention so that serum levels increase (hyperuricemia). Hyperuricemia...

Background: Although it has been suggested that hyperuricemia and gout are predictive of the future risk atrial fibrillation, there is still a lack epidemiological evidence. Objective: Through an updated systematic review meta-analysis, we aimed to assess association between hyperuricemia/gout fibrillation. Methods: We performed search EMBASE, PubMed, Web Science from their establishment Septem...

Introduction: Uric acid is the end product of purine metabolism in humans due to the loss of uricase activity. Elevated uric acid is one of the metabolic abnormalities associated with cardiovascular disease. There are some studies found that hyperuricemia has been linked with cardiovascular diseases. Hyperuricemia predispose to the development of hypertension and is also thought to result in in...

BACKGROUND Observational studies of the relationship between hyperuricemia and the incidence of hypertension are controversial. We conducted a systematic review and meta-analysis to assess the association and consistency between uric acid levels and the risk of hypertension development. METHODS We searched MEDLINE, EMBASE, CBM (Chinese Biomedicine Database) through September 2013 and referenc...

The question of whether hyperuricemia can induce chronic direct renal injury has been argued for many decades. Despite continued efforts and strong motivations to seek an answer, the current evidence still cannot definitively prove or refute the hypothesis. Recent data in rodents do favor causality between hyperuricemia and renal disease. Human epidemiologic data are quite varied, but positive ...

We have observed that the elevated plasma adenosine levels are associated with hyperuricemia in nonpreeclamptic twin pregnancies. In animal models, extracellular adenosine is taken up by cells to form adenine nucleotides or is degraded to other purine metabolites such as hypoxanthine, which is further metabolized to xanthine and uric acid. In this study, we measured plasma hypoxanthine levels t...