Resveratrol is a nonflavonoid polyphenolic compound which has a broad range of desirable biological actions which include antioxidant, anti-inflammatory, antidiabetic, cardioprotective, and antitumor activities. However, there is concern that the bioavailability of resveratrol may limit some of its clinical utility. So, the aim of this study was to enhance the dissolution rate and oral hypoglyc...

INTRODUCTION AND OBJECTIVES In Spain, use of the Framingham-REGICOR (Registre Gironí del Cor) and SCORE (Systematic Coronary Risk Evaluation) risk charts is recommended for stratifying cardiovascular disease risk. The aims of the present study were to evaluate the degree of agreement between these charts when used to evaluate cardiovascular disease risk in nondiabetic individuals aged 40-65 yea...

Aims: To investigate seasonal variation in anti-diabetic and hypolipidemic activities of Momordica charantia fruits harvested at different seasons of the year, namely spring, summer, autumn and winter. Methodology: Air-dried and pulverized fruit samples were extracted by soaking in 70% methanol for 72h. The filtrate was concentrated using rotary evaporator. The yields of spring (MME), summer (J...

Maslinic acid is a pentacyclic triterpenoid acid. Recent research has shown that it various biological activities such as anti-tumor, hypoglycaemic and hypolipidemic. Among them, the hypolipidemic effect prominent this study aims to further explore its mechanism of action in treatment hyperlipidemia. The chemical structure maslinic was obtained from PubChem. Based on structure, bioavailability ...

BACKGROUND: Despite the available range of lipid-lowering drugs, mainly synthetic origin, problem atherosclerosis therapy and its manifestations remain unresolved. Bioinformatics methods, in particular molecular docking, are considered as a promising direction terms developing effective original drugs. Today, source natural agents, it is advisable to consider terpenoids, namely sesquiterpene la...

In traditional Chinese medicine (TCM), purgation is indicated when a person suffers an illness due to the accumulation of evil internal heat. Obese individuals with a large belly, red face, thick and yellow tongue fur, constipation, and avoidance of heat are thought accumulates of evil internal heat, and they are also treated with purgatives such as Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang ...

BACKGROUND Studies demonstrated that visit-to-visit variability in low-density lipoprotein cholesterol (LDLC) is an independent predictor of cardiovascular events in subjects with coronary artery disease. Whether visit-to-visit variability in LDLC levels affects subclinical atherosclerosis is unknown. This study sought to evaluate the role of visit-to-visit variability in LDLC levels on subclin...