BACKGROUND Elevated serum cholesterol levels are associated with increased risk for acute myocardial infarction (AMI) and adverse patient outcomes. It is unclear what proportion of patients have their serum cholesterol levels measured during hospitalization for AMI and are given hypolipidemic therapy. OBJECTIVE To examine decade-long trends in measurement of serum cholesterol levels during ho...

Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes, enhance the activity of peroxisome-associated beta-oxidation of fatty acids, and produce hepatocellular carcinomas in the livers of rodents. Because these chemicals themselves are not mutagens and do not covalently modify DNA, unlike the majority of chemical carcinogens, we proposed that the per...

BACKGROUND Central to the pathology of coronary heart disease is the accumulation of lipids, cholesterol and triglycerides, within the intima of arterial blood vessels. The search for drugs to treat dislipidemia, remains a major pharmaceutical focus. In this study, we evaluated the hypolipidemic properties of the essential oil from Chios mastic gum (MGO). METHODOLOGY/PRINCIPAL FINDINGS The hy...

Patients with familial hypercholesterolemia (FH) have had a life-long sustained elevation of low-density lipoprotein (LDL) cholesterol levels. Consequently, there is a need to maximally lower their elevated levels, and this usually requires lowering LDL levels more than 50%. Because no single hypolipidemic drug will consistently produce such degrees of lowering, combination drug therapy with tw...

The beneficial effects of statins are the result of their capacity to reduce cholesterol biosyntesis, mainly in the liver, where they are selectively distributed, as well as to the modulation of lipid metabolism, derived from their effect of inhibition upon HMG-CoA reductase. Statins have antiatherosclerotic effects, that positively correlate with the percent decrease in LDL cholesterol. In add...

BLACK The importance of herbal hypolipidemics has increased to fill the lacunae created by allopathic medicines. Coriander is a spice, which is used in daily cooking especially in India. In Ayurvedic literature it is reported to possess hypolipidemic activity. Hence, to validate these ancient known property researchers at International Institute of Biotechnology and Toxicology, Padappai, Tamil ...

two proprotein convertase subtilisin/kexin type 9 (PcsK9) inhibitors, evolocumab and alirocumab, have recently been approved by both the food and drug Administration (fdA) and the european Medicines Agency (eMA) for the treatment of hypercholesterolemia. these fully human monoclonal antibodies selectively block PcsK9, thus permitting the low-density lipoprotein (LdL) receptor to effectively rec...

The effects of blueberry leaf (BBL) on lipid metabolism were studied in obese rats. Feeding of BBL lowered levels of serum lipids and C-reactive protein and alleviated hepatic triglyceride accumulation in the rats. The hypolipidemic effect might be attributable to a reduction of lipogenesis and enhancement of lipolysis in the liver. These results suggest the use of blueberry leaf as a dietary h...

objective: turmeric (curcuma longa linn) is a medicinal plant that contains curcumin. there is a growing interest in using curcumin powder (cp) as feed additives for antioxidative and antimicrobial properties to improve human health. this study was conducted to determine the appropriate levels of cp on blood parameters, immunity, and histology of jejunum in hens. materials and methods: a total ...