The hypoglycaemic and hypolipidemic effects of the aqueous extract of Ocimum basilicum (OB) whole plant were investigated in normal and streptozotocin (STZ) diabetic rats. After a single oral administration, OB significantly reduced blood glucose levels in normal (p<0.01) and diabetic rats (p<0.001). After 15 days of repeated oral administration, OB produced a potent reduction on blood glucose ...

We studied the mechanisms of hypolipidemic effects of NIP-200 (3,5-dimethyl-4,6-diphenyltetrahydro-2H-1,3,5-thiadiazine- 2-thione), a potent hypolipidemic compound, in cholesterol biosynthesis in the liver, cholesterol absorption in small intestine, and cholesterol catabolism and excretion in rats. NIP-200 did not reduce cholesterol biosynthesis and had no effects on cholesterol absorption in t...

Cardiovascular diseases continue to be a leading cause of morbidity and mortality in developed as well as developing countries. Hypercholesterolemia is one of the factors that have contributed in acceleration of Coronary Heart Diseases in India. It is associated with elevated lipid levels in the blood. Treatment of hypercholesterolemia is one of the major approaches towards decelerating the ath...

PURPOSE OF REVIEW The hypolipidemic and antiobesogenic effects of tea intake have been associated with bioactive compounds that regulate peroxisome proliferator-activated receptors (PPARs). This review describes the recent research on two of these compounds, (-)-epigallocatechin gallate (EGCG) and linalool. RECENT FINDINGS Catechins (specifically EGCG) are key bioactive compounds found in tea...

Bottle gourd [(Lagenaria siceraria (Mol.) Stand.] fruit is ascribed with many therapeutic effects. The present study was undertaken to explore the antihyperlipidemic effect of four different extracts viz. petroleum ether, chloroform, alcoholic and aqueous extracts from bottle gourd in Triton-induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is com...

A series of curcumin pyrazole derivatives (3a-3e) were investigated for in-vitro hypolipidemic activity. The compounds were screened for the inhibition studies of the enzymes such as pancreatic lipase, glucose 6 phosphate dehydrogenase and malate dehydrogenase which are actively involved in lipid metabolism. Curcumin and all the other compounds in the series showed differential enzyme inhibitor...

The pancreatic lipase inhibitory activity of the rhizome of Alpinia officinarum (AO) and its antihyperlipidemic activity were measured. When the water extract of AO was fractionated stepwise with organic solvents, the ethyl acetate fraction exhibited the most potent inhibition. 3-Methylethergalangin was isolated from that fraction as an inhibitor of pancreatic lipase with an IC(50) value of 1.3...