MODY-5 is a rare autosomal dominant form of monogenic diabetes attributed to deletions chromosome 17q12 with impaired expression HNF1β (Hepatocyte Nuclear Factor 1 homeobox Beta. The deficient HNF1B down regulated the FXYD2. Refractory hypomagnesemia commonly observed in patients due downregulated FXYD2 which blocked encoding γ (gamma) subunit Na+-K+-ATPase and indirectly led hypomagnesemia. SG...

Magnesium is the second most common intracellular cation and serves as an important metabolic cofactor to over 300 enzymatic reactions throughout the human body. Among its various roles, magnesium modulates calcium entry and release from sarcoplasmic reticulum and regulates ATP pumps in myocytes and neurons, thereby regulating cardiac and neuronal excitability. Therefore, deficiency of this ess...

CONTEXT Magnesium support to small bowel resection patients. OBJECTIVE Incidence and treatment of hypomagnesemia in patients with extensive small bowel resection. DESIGN Retrospective study. SETTING Metabolic Unit of the University Hospital Medical School of Ribeirão Preto, University of São Paulo, Brazil. PATIENTS Fifteen patients with extensive small bowel resection who developed shor...

Although both hypokalemia and hypomagnesemia have been linked with life-threatening cardiac arrhythmias, published studies disagree regarding the frequency of simultaneously low serum potassium and magnesium concentrations. To investigate the possible associations between the concentrations of these ions in serum, we carried out a retrospective study of all paired magnesium-potassium measuremen...

BACKGROUND Brachycephalic dogs are at risk for arterial hypertension and obstructive sleep apnea, which are both associated with chronic magnesium (Mg) depletion. HYPOTHESIS/OBJECTIVES To compare the period prevalence of hypomagnesemia between Boxers and Bulldogs presented to a referral teaching hospital. To screen a group of Bulldogs for evidence of hypomagnesemia, and to obtain pilot data r...