Increased tissue permeability is commonly associated with hypoxia of many origins. Since hypoxia-inducible factor (HIF) represents a predominant hypoxia signaling mechanism, we compared hypoxia-elicited changes in tissue barrier function in mice conditionally lacking intestinal epithelial hypoxia-inducible factor-1alpha (hif1a). Somewhat surprisingly, these studies revealed that mutant hif1a mi...

One of the most fundamental molecular processes in response to hypoxia is activation and stabilization a transcriptional factor called induced 1a (HIF-1a), which responsible for regulation many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, metastasis are governed by these This article discusses role hypoxia-inducible (HIF-1a) met...

Antibiotics inhibit breast cancer stem cells (CSCs) by suppressing mitochondrial biogenesis. However, the effectiveness of antibiotics in clinical settings is inconsistent. This inconsistency raises question whether tumor microenvironment, particularly hypoxia, plays a role response to antibiotics. Therefore, goal this study was evaluate five commonly used for inhibiting CSCs under hypoxia usin...

The Haihe River system is a major conduit of land-based pollution into the Bohai Sea in North China, This study presented first-ever observation hypoxia estuary, providing valuable insights complex interplay between physical and biochemical factors influencing estuarine systems. research found seasonal variations DO distribution estuaries Yongdingxin Rivers. Hypoxia emerged summer at bottom est...

The oxygen sensitive alpha-subunit of the hypoxia-inducible factor-1 (HIF-1) is a major trigger of the cellular response to hypoxia. Although the posttranslational regulation of HIF-1alpha by hypoxia is well known, its transcriptional regulation by hypoxia is still under debate. We, therefore, investigated the regulation of HIF-1alpha mRNA in response to hypoxia in pulmonary artery smooth muscl...

Purpose There is a need for adjuvant/neo-adjuvant treatment strategies to prevent metastatic relapse in soft tissue sarcoma (STS). Tumor hypoxia is associated with a high-risk of metastasis and is potentially targetable. This study aimed to derive and validate a hypoxia mRNA signature for STS for future biomarker-driven trials of hypoxia targeted therapy. Materials and Methods RNA sequencing ...

Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose activity is modulated by a variety of signals. Energy depletion and hypoxia result in mTOR inhibition. While energy depletion inhibits mTOR through a process involving the activation of AMP-activated protein kinase (AMPK) by LKB1 and subsequent phosphorylation of TSC2, the mechanism of mTOR inhibition by hypo...

Intratumoral hypoxia is associated with resistance to therapy in many human cancers, and preexposure of tumor cells to hypoxia confers multidrug resistance. Whereas most anticancer drugs kill proliferating tumor cells by causing DNA damage, a role for hypoxia in the prevention and/or repair of drug-induced DNA damage has not been clear. Using the alkaline comet assay, we provide direct evidence...

A lot of salt-affected soils in the world are also affected by compaction and waterlogging due to shallow water tables or decreased infiltration sodicity. Waterlogging cause reduced oxygen exchange (hypoxia). Research on combined impacts salinity hypoxia turfgrass growth is limited. The interactive effects availability nine perennial ryegrass entries (Lolium perenne L.) one alkaligrass [Puccine...

Alterations in fish developmental trajectories occur response to genetic and environmental changes, especially during sensitive periods of development (critical windows). Embryos larvae Atractosteus tropicus were used as a model study survival, growth, function temperature (28 °C control, 33 °C, 36 °C), salinity (0.0 ppt 4.0 ppt, 6.0 ppt), air saturation (control ~95% saturation, hypoxia ~30% h...