Abstract Objective This study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression survival outcome in advanced pharyngeal cancer without human papillomavirus infection. Method Twenty-five oropharyngeal 55 hypopharyngeal patients infection were enrolled. All had stage III–IV lesions underwent concurrent chemoradiotherapy or surgery....

Hypoxia and iron both regulate metabolism through multiple mechanisms, including hypoxia-inducible transcription factors. The hypoxic effects on glucose disposal and glycolysis are well established, but less is known about the effects of hypoxia and iron deficiency on hepatic gluconeogenesis. We therefore assessed their effects on hepatic glucose production in mice. Weanling C57BL/6 male mice w...

In the present era of ever-increasing antibiotic resistance and increasingly complex and immunosuppressed patient populations, physicians and scientists are seeking novel approaches to battle difficult infectious disease conditions. Development of a serious infection implies a failure of innate immune capabilities in the patient, and one may consider whether pharmacological strategies exist to ...